Concepedia

Protein Function Dissection

Protein Function Dissection is a systematic experimental approach within forward chemical genetics that identifies and characterizes the specific biological roles and mechanistic activities of proteins by analyzing phenotypic changes induced by small-molecule perturbations, thereby linking molecular function to cellular phenotype.

62

Publications

3.4K

Citations

349

Authors

133

Institutions

Publications per year

2017–2026

14

Parents

Publications

62

A Method for the Acute and Rapid Degradation of Endogenous Proteins

Dean Clift, William A. McEwan, Larisa I. Labzin et al. · Cell · 2017 · 539 citations · Full text

, , +15

Prediction of Human Protein Function from Post-translational Modifications and Localization Features

Lars Juhl Jensen, Ramneek Gupta, Nikolaj Blom et al. · Journal of Molecular Biology · 2002 · 324 citations

, , +16

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

Dominic Hoepfner, Stephen B. Helliwell, Heather Sadlish et al. · Microbiological Research · 2013 · 184 citations

, , +11

Protein Splicing Triggered by a Small Molecule

Henning D. Mootz, Tom W. Muir · Journal of the American Chemical Society · 2002 · 159 citations

, , +13

Structure–Function Analysis of the ADAM Family of Disintegrin-Like and Metalloproteinase-Containing Proteins (Review)

Anne L. Stone, Michaela Kroeger, Qing Sang · Journal of Protein Chemistry · 1999 · 153 citations

, , +16

1–5 of 62

Authors

349

  1. MA
    Markus Affolter

    University of Basel, Switzerland

    2 publications · 63 citations

    2

    h-index

  2. SR
    Susan Rowland

    The University of Queensland, Australia

    2 publications · 27 citations

    2

    h-index

  3. GF
    Glenn F. King

    The University of Queensland, Australia

    2 publications · 27 citations

    2

    h-index

  4. KD
    Kimberly D. Wadsworth

    Research Institute for Bioscience and Biotechnology, Nepal

    2 publications · 27 citations

    2

    h-index

  5. DA
    Davide Andrenacci

    University of Bologna, Italy

    2 publications · 46 citations

    2

    h-index

1–5 of 349

Institutions

133

  1. Heidelberg University

    Heidelberg, Germany

    3 h-index

    25 publications

    1K citations

  2. The University of Queensland

    Brisbane, Australia

    3 h-index

    17 publications

    523 citations

  3. University Hospital Heidelberg

    Heidelberg, Germany

    3 h-index

    7 publications

    405 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    19 publications

    913 citations

  5. Consejo Superior de Investigaciones Científicas

    Madrid, Spain

    2 h-index

    5 publications

    1K citations

  6. Rockefeller University

    New York, United States

    2 h-index

    3 publications

    361 citations

  7. University of Basel

    Basel, Switzerland

    2 h-index

    7 publications

    220 citations

  8. Institute of Genetics and Biophysics

    Naples, Italy

    2 h-index

    6 publications

    144 citations

1–8 of 133

Venues

  1. PLoS ONE

    4 publications · 263 citations

    4

    h-index

  2. Journal of Biological Chemistry

    JBC · 2 publications · 107 citations

    2

    h-index

  3. Journal of Bacteriology

    JB · 2 publications · 34 citations

    2

    h-index

  4. Analytical Biochemistry

    2 publications · 46 citations

    2

    h-index

  5. Journal of Virology

    JVI · 2 publications · 74 citations

    2

    h-index

1–5