Concepedia

Protein C System

The "Protein C System" is a natural anticoagulant mechanism within the coagulation cascade that selectively inactivates coagulation factors Va and VIIIa through activated protein C, thereby negatively regulating thrombin generation and preventing excessive clot formation.

1.3K

Publications

87.6K

Citations

4.5K

Authors

1K

Institutions

Publications per year

2017–2026

46

Variants

Protein C Anticoagulant System

Parents

Publications

1.3K

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

Björn Dahlbäck, Martin Carlsson, Peter J. Svensson · Proceedings of the National Academy of Sciences · 1993 · 2K citations

, , +15

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

Ted Koster, FR Rosendaal, Hans de Ronde et al. · The Lancet · 1993 · 1.3K citations

, , +14

Deficiency of protein C in congenital thrombotic disease.

John H. Griffin, B. L. Evatt, T S Zimmerman et al. · Journal of Clinical Investigation · 1981 · 1.3K citations · Full text

, , +14

Resistance to Activated Protein C as a Basis for Venous Thrombosis

Peter J. Svensson, Björn Dahlbäck · New England Journal of Medicine · 1994 · 1.1K citations · Full text

, , +13

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

Charles T. Esmon, Whyte G. Owen · Proceedings of the National Academy of Sciences · 1981 · 838 citations · Full text

, , +15

1–5 of 1.3K

Authors

4.5K

  1. CT
    Charles T. Esmon

    Oklahoma Medical Research Foundation, United States

    58 publications · 10.6K citations

    43

    h-index

  2. JH
    John H. Griffin

    Scripps Research Institute, United States

    65 publications · 5K citations

    34

    h-index

  3. BD
    Björn Dahlbäck

    Lund University, Sweden

    56 publications · 7K citations

    33

    h-index

  4. JA
    José A. Fernández

    Scripps Research Institute, United States

    30 publications · 1.6K citations

    21

    h-index

  5. RM
    Rogier M. Bertina

    Leiden University, Netherlands

    24 publications · 2.4K citations

    20

    h-index

1–5 of 4.5K

Institutions

1K

  1. Oklahoma Medical Research Foundation

    Oklahoma City, United States

    47 h-index

    207 publications

    30.6K citations

  2. Scripps Research Institute

    San Diego, United States

    35 h-index

    225 publications

    14.8K citations

  3. Lund University

    Lund, Sweden

    34 h-index

    168 publications

    15.4K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    33 h-index

    98 publications

    14K citations

  5. University of Oklahoma Health Sciences Center

    Oklahoma City, United States

    28 h-index

    77 publications

    15.2K citations

  6. Leiden University

    Leiden, The Netherlands

    25 h-index

    87 publications

    15.4K citations

  7. Scripps Health

    San Diego, United States

    23 h-index

    82 publications

    15.1K citations

  8. University of Vermont

    Burlington, United States

    22 h-index

    117 publications

    8.5K citations

1–8 of 1K

Venues

  1. Blood

    139 publications · 13.1K citations

    65

    h-index

  2. Journal of Biological Chemistry

    JBC · 84 publications · 8.7K citations

    51

    h-index

  3. Thrombosis and Haemostasis

    128 publications · 7.8K citations

    48

    h-index

  4. The Journal of Immunology

    JI · 53 publications · 3.7K citations

    34

    h-index

  5. PubMed

    Repository · 93 publications · 4K citations

    33

    h-index

1–5