Concepedia

Protein Binding Interface Design

Protein Binding Interface Design is the computational or experimental methodology aimed at creating or optimizing the specific region of a protein that mediates selective and stable interactions with a target biomolecule, distinguishing it from general protein design by focusing exclusively on the structural and energetic determinants of intermolecular recognition and binding affinity.

104

Publications

8K

Citations

548

Authors

173

Institutions

Publications per year

2017–2026

32

Parents

Publications

104

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

Sarel J. Fleishman, Timothy A. Whitehead, Damian C. Ekiert et al. · Science · 2011 · 597 citations

, , +17

The LIM domain is a modular protein-binding interface

Karen Schmeichel · Cell · 1994 · 454 citations

, , +14

Structural and thermodynamic analysis of the GFP:GFP‐nanobody complex

Marta H. Kubala, Oleksiy Kovtun, Kirill Alexandrov et al. · Protein Science · 2010 · 436 citations · Full text

, , +17

Minimizing a binding domain from protein A.

Andrew C. Braisted, James A. Wells · Proceedings of the National Academy of Sciences · 1996 · 306 citations

, , +17

Rational design of faster associating and tighter binding protein complexes.

Gideon Schreiber, Tzvia Selzer, Shira Albeck · Nature Structural Biology · 2000 · 304 citations

, , +16

1–5 of 104

Authors

548

  1. DB
    David Baker

    University of Washington, United States

    5 publications · 927 citations

    5

    h-index

  2. BK
    Brian Kuhlman

    University of North Carolina at Chapel Hill, United States

    4 publications · 399 citations

    4

    h-index

  3. TK
    Tanja Kortemme

    University of California, San Francisco, United States

    4 publications · 444 citations

    4

    h-index

  4. GS
    Gideon Schreiber

    Weizmann Institute of Science, Israel

    4 publications · 626 citations

    4

    h-index

  5. SK
    Shohei Koide

    University of Chicago, United States

    3 publications · 323 citations

    3

    h-index

1–5 of 548

Institutions

173

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    12 publications

    1.8K citations

  2. University of Washington

    Seattle, United States

    7 h-index

    19 publications

    3.9K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    5 h-index

    14 publications

    1.1K citations

  4. Weizmann Institute of Science

    Rehovot, Israel

    4 h-index

    20 publications

    2.9K citations

  5. Washington University in St. Louis

    St Louis, United States

    4 h-index

    15 publications

    1.1K citations

  6. University of Chicago

    Chicago, United States

    4 h-index

    19 publications

    1.8K citations

  7. Scripps Research Institute

    San Diego, United States

    4 h-index

    10 publications

    3.1K citations

  8. Harvard University

    Cambridge, United States

    4 h-index

    9 publications

    772 citations

1–8 of 173

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 1.8K citations

    15

    h-index

  2. Journal of Biological Chemistry

    JBC · 12 publications · 505 citations

    12

    h-index

  3. Journal of Molecular Biology

    JMB · 9 publications · 637 citations

    9

    h-index

  4. Biochemistry

    6 publications · 157 citations

    6

    h-index

  5. Protein Science

    PS · 5 publications · 793 citations

    5

    h-index

1–5