Concepedia

Protease Structure Function Relationships

Protease Structure Function Relationships is a theoretical framework that elucidates the mechanistic interdependence between the three-dimensional architectural features of proteolytic enzymes and their catalytic or regulatory activities, distinguishing it from general enzyme structure–function models by focusing specifically on the structural determinants governing substrate specificity, catalytic efficiency, and inhibition in proteases.

295

Publications

15K

Citations

1.6K

Authors

499

Institutions

Publications per year

2017–2026

87

Variants

Protease Structure-function Relationships

Parents

Publications

295

Cysteine cathepsins: From structure, function and regulation to new frontiers

Vito Türk, Veronika Stoka, Olga Vasiljeva et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2011 · 1.4K citations · Full text

, , +17

The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human <i>α</i>‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships

Wolfram Bode, Andrej Karshikov · Protein Science · 1992 · 626 citations · Full text

, , +17

Structural basis for the regulated protease and chaperone function of DegP

T. Krojer, Justyna Sawa‐Makarska, Eva Schäfer et al. · Nature · 2008 · 373 citations

, , +16

Redesigning Trypsin: Alteration of Substrate Specificity

Charles S. Craik, Corey Largman, Thomas S. Fletcher et al. · Science · 1985 · 365 citations

, , +17

Crystal structure of a retroviral protease proves relationship to aspartic protease family

Maria Miller, Mariusz Jaskólski, Jayasimha Rao et al. · Nature · 1989 · 344 citations

, , +16

1–5 of 295

Authors

1.6K

  1. AW
    Alexander Wlodawer

    Frederick National Laboratory for Cancer Research, United States

    6 publications · 489 citations

    6

    h-index

  2. MJ
    Mariusz Jaskólski

    Adam Mickiewicz University in Poznań, Poland

    6 publications · 677 citations

    6

    h-index

  3. WR
    W.S. Rickert

    University of Waterloo, Canada

    4 publications · 65 citations

    4

    h-index

  4. CS
    Charles S. Craik

    University of California, San Francisco, United States

    4 publications · 522 citations

    4

    h-index

  5. WC
    William C. Groutas

    Wichita State University, United States

    3 publications · 91 citations

    3

    h-index

1–5 of 1.6K

Institutions

499

  1. National Institutes of Health

    Bethesda, United States

    7 h-index

    24 publications

    4.9K citations

  2. University of California, San Francisco

    San Francisco, United States

    6 h-index

    28 publications

    2.5K citations

  3. University of KwaZulu-Natal

    Durban, South Africa

    5 h-index

    18 publications

    377 citations

  4. Adam Mickiewicz University in Poznań

    Poznan, Poland

    5 h-index

    6 publications

    812 citations

  5. Max Planck Institute of Biochemistry

    Martinsried, Germany

    5 h-index

    12 publications

    2.8K citations

  6. Lund University

    Lund, Sweden

    4 h-index

    8 publications

    445 citations

  7. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    4 h-index

    6 publications

    800 citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    13 publications

    538 citations

1–8 of 499

Venues

  1. Journal of Molecular Biology

    JMB · 18 publications · 1.2K citations

    16

    h-index

  2. Bioorganic & Medicinal Chemistry

    12 publications · 360 citations

    12

    h-index

  3. Journal of Biological Chemistry

    JBC · 11 publications · 537 citations

    10

    h-index

  4. Protein Science

    PS · 9 publications · 999 citations

    9

    h-index

  5. Biochemical Journal

    BJ · 8 publications · 234 citations

    8

    h-index

1–5