Concepedia

Protease Resistance Optimization

Protease Resistance Optimization is a peptidomimetic design strategy that enhances the metabolic stability of peptide-based therapeutics by systematically modifying molecular structures to minimize enzymatic degradation by proteases while preserving biological activity.

21

Publications

725

Citations

164

Authors

43

Institutions

Publications per year

2017–2026

4

Parents

Publications

21

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

C. Nicholas Hodge, Paul E. Aldrich, Lee T. Bacheler et al. · Chemistry & Biology · 1996 · 148 citations · Full text

, , +16

Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High‐Resolution Structure of the Oncocin‐DnaK Complex

Daniel Knappe, Michael Zahn, Ute Sauer et al. · ChemBioChem · 2011 · 89 citations

, , +17

Engineering of protease-resistant phytase from Penicillium sp.: High thermal stability, low optimal temperature and pH

Qianqian Zhao, Honglei Liu, Ying Zhang et al. · Journal of Bioscience and Bioengineering · 2010 · 53 citations

, , +17

Design and Construction of Highly Stable, Protease-resistant Chimeric Avidins

Vesa P. Hytönen, Juha A. E. Määttä, Thomas K.M. Nyholm et al. · Journal of Biological Chemistry · 2005 · 52 citations · Full text

, , +12

Design of protease-resistant peptide ligands for the purification of antibodies from human plasma

Stefano Menegatti, Benjamin G. Bobay, Kevin Lawrence Ward et al. · Journal of Chromatography A · 2016 · 44 citations

, , +14

1–5 of 21

Authors

164

  1. AC
    Anil C. Nair

    University of Missouri–St. Louis, United States

    2 publications · 29 citations

    2

    h-index

  2. SM
    Stanislav Miertuš

    AREA Science Park, Italy

    2 publications · 29 citations

    2

    h-index

  3. AT
    Alessandro Tossi

    University of Trieste, Italy

    2 publications · 29 citations

    2

    h-index

  4. NK
    Neşe Kurt Yılmaz

    University of Massachusetts Chan Medical School, United States

    1 publications · 30 citations

    1

    h-index

  5. MS
    Muriel Subirade

    Université Laval, Canada

    1 publications · 42 citations

    1

    h-index

1–5 of 164

Institutions

43

  1. AREA Science Park

    Trieste, Italy

    2 h-index

    4 publications

    58 citations

  2. University of Trieste

    Trieste, Italy

    2 h-index

    4 publications

    58 citations

  3. Scripps Research Institute

    San Diego, United States

    1 h-index

    5 publications

    100 citations

  4. University of Eastern Finland

    Joensuu, Finland

    1 h-index

    1 publications

    52 citations

  5. China Institute of Veterinary Drug Control

    Beijing, China

    1 h-index

    1 publications

    53 citations

  6. Nanjing Agricultural University

    Nanjing, China

    1 h-index

    1 publications

    38 citations

  7. Hebrew University of Jerusalem

    Jerusalem, Israel

    1 h-index

    2 publications

    104 citations

  8. University of California, Santa Barbara

    Santa Barbara, United States

    1 h-index

    6 publications

    108 citations

1–8 of 43

Venues

  1. Journal of Medicinal Chemistry

    2 publications · 40 citations

    2

    h-index

  2. ChemBioChem

    2 publications · 113 citations

    2

    h-index

  3. Expert Opinion on Pharmacotherapy

    1 publications · 22 citations

    1

    h-index

  4. Journal of Bioscience and Bioengineering

    1 publications · 53 citations

    1

    h-index

  5. Chemical Communications

    ChemComm · 1 publications · 18 citations

    1

    h-index

1–5