Concepedia

Properdin Modulation

Properdin Modulation is a pharmacological intervention strategy that selectively enhances or inhibits the functional activity of properdin, a positive regulator of the alternative complement pathway, to attenuate or potentiate complement-mediated immune responses in a targeted manner.

19

Publications

1.3K

Citations

95

Authors

48

Institutions

Publications per year

2017–2026

4

Parents

Publications

19

Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

Douglas T. Fearon, K. Frank Austen · The Journal of Experimental Medicine · 1975 · 475 citations · Full text

, , +13

Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway.

R G Medicus, Otto Götze, Hans J. Müller‐Eberhard · The Journal of Experimental Medicine · 1976 · 204 citations · Full text

, , +16

Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement

Yuko Kimura, Takashi Miwa, Lin Zhou et al. · Blood · 2007 · 118 citations · Full text

, , +11

Alterations in Serum Properdin Levels Following Injection of Zymosan

Louis Pillemer, Oscar A. Ross · Science · 1955 · 93 citations

, , +4

Functional and structural insight into properdin control of complement alternative pathway amplification

Dennis Pedersen, Lubka T. Roumenina, Rasmus K. Jensen et al. · The EMBO Journal · 2017 · 70 citations · Full text

, , +13

1–5 of 19

Authors

95

  1. CS
    Cordula Stover

    University of Leicester, United Kingdom

    4 publications · 181 citations

    4

    h-index

  2. RG
    R G Medicus

    Scripps Health, United States

    3 publications · 245 citations

    3

    h-index

  3. HJ
    Hans J. Müller‐Eberhard

    Scripps Health, United States

    3 publications · 245 citations

    3

    h-index

  4. GA
    G.R. Andersen

    Aarhus University, Denmark

    3 publications · 106 citations

    3

    h-index

  5. DP
    Dennis Pedersen

    Aarhus University, Denmark

    3 publications · 106 citations

    3

    h-index

1–5 of 95

Institutions

48

  1. University of Leicester

    Leicester, United Kingdom

    4 h-index

    7 publications

    275 citations

  2. Aarhus University

    Aarhus, Denmark

    3 h-index

    10 publications

    492 citations

  3. University of Pennsylvania

    Philadelphia, United States

    3 h-index

    6 publications

    536 citations

  4. Translational Therapeutics (United States)

    Arlington, United States

    2 h-index

    5 publications

    515 citations

  5. Université Laval

    Québec, Canada

    2 h-index

    8 publications

    327 citations

  6. University of Oxford

    Oxford, United Kingdom

    2 h-index

    8 publications

    138 citations

  7. Institut universitaire de cardiologie et de pneumologie de Québec

    Québec, Canada

    2 h-index

    8 publications

    327 citations

  8. Cardiff University

    Cardiff, United Kingdom

    1 h-index

    4 publications

    104 citations

1–8 of 48

Venues

  1. The Journal of Experimental Medicine

    3 publications · 727 citations

    3

    h-index

  2. Molecular Immunology

    2 publications · 85 citations

    2

    h-index

  3. Science

    1 publications · 93 citations

    1

    h-index

  4. Biochemical and Biophysical Research Communications

    BBRC · 1 publications · 58 citations

    1

    h-index

  5. The EMBO Journal

    1 publications · 70 citations

    1

    h-index

1–5