Concepedia

Promoter Modularity

Promoter Modularity is a design principle in synthetic biology whereby a promoter is structured as a composite regulatory element composed of distinct, interchangeable functional units—such as operator sites, transcription factor binding sites, and core promoter motifs—that can be systematically rearranged or swapped to predictably alter transcriptional output without disrupting overall promoter function.

8

Publications

1.1K

Citations

28

Authors

9

Institutions

Publications per year

2017–2026

3

Parents

Publications

8

Revealing modular organization in the yeast transcriptional network

Jan Ihmels, Gilgi Friedlander, Sven Bergmann et al. · Nature Genetics · 2002 · 704 citations

, , +11

TATA is a modular component of synthetic promoters

Ilaria Mogno, Francesco Vallania, Robi D. Mitra et al. · Genome Research · 2010 · 107 citations · Full text

, , +17

Orthogonal Modular Gene Repression in <i>Escherichia coli</i> Using Engineered CRISPR/Cas9

Andriy Didovyk, Bartłomiej Borek, Jeff Hasty et al. · ACS Synthetic Biology · 2015 · 67 citations

, , +17

Genomic environments scale the activities of diverse core promoters

Clarice KY Hong, Barak A. Cohen · Genome Research · 2021 · 57 citations · Full text

, , +17

In silico design of context-responsive mammalian promoters with user-defined functionality

Adam Brown, Suzanne J. Gibson, Diane Hatton et al. · Nucleic Acids Research · 2017 · 44 citations · Full text

, , +17

1–5 of 8

Authors

28

  1. BA
    Barak A. Cohen

    Washington University in St. Louis, United States

    2 publications · 164 citations

    2

    h-index

  2. TW
    Thomas Werner

    Heinrich Heine University Düsseldorf, Germany

    1 publications · 33 citations

    1

    h-index

  3. CK
    Clarice KY Hong

    Washington University in St. Louis, United States

    1 publications · 57 citations

    1

    h-index

  4. DL
    David Lebœuf

    Centre National de la Recherche Scientifique, France

    1 publications · 27 citations

    1

    h-index

  5. RJ
    Robert J. Mayer

    Dana-Farber Cancer Institute, United States

    1 publications · 27 citations

    1

    h-index

1–5 of 28

Institutions

9

  1. Washington University in St. Louis

    St Louis, United States

    2 h-index

    6 publications

    542 citations

  2. Weizmann Institute of Science

    Rehovot, Israel

    1 h-index

    6 publications

    4.2K citations

  3. University of California San Diego

    San Diego, United States

    1 h-index

    4 publications

    268 citations

  4. University of Sheffield

    Sheffield, United Kingdom

    1 h-index

    2 publications

    88 citations

  5. Center for Systems Biology

    Boston, United States

    1 h-index

    4 publications

    268 citations

  6. Université de Strasbourg

    Strasbourg, France

    1 h-index

    4 publications

    108 citations

  7. Software (Germany)

    Darmstadt, Germany

    1 h-index

    1 publications

    33 citations

  8. Institut Universitaire de France

    Paris, France

    1 h-index

    1 publications

    27 citations

1–8 of 9

Venues

  1. Genome Research

    GR · 2 publications · 164 citations

    2

    h-index

  2. Nature Genetics

    1 publications · 704 citations

    1

    h-index

  3. The EMBO Journal

    1 publications · 29 citations

    1

    h-index

  4. ACS Catalysis

    1 publications · 27 citations

    1

    h-index

  5. PubMed

    Repository · 1 publications · 33 citations

    1

    h-index

1–5