Transcriptome‐Based Identification of the Optimal Reference CHO Genes for Normalisation of qPCR Data

Adam Brown, Suzanne J. Gibson, Diane Hatton, +1

Biotechnology Journal

EngineeringGeneticsMolecular BiologyTranscriptomics TechnologyGene Characterization +19

In silico design of context-responsive mammalian promoters with user-defined functionality

Adam Brown, Suzanne J. Gibson, Diane Hatton, +1

Nucleic Acids Research

EngineeringMolecular BiologySynthetic CircuitBiological ComputingGene Regulatory Network +18

Whole synthetic pathway engineering of recombinant protein production

Adam Brown, Suzanne J. Gibson, Diane Hatton, +2

Biotechnology and Bioengineering

Host Cell ChassisEngineeringMolecular BiologySynthetic CircuitBiosynthesis +15

N‐terminal or signal peptide sequence engineering prevents truncation of human monoclonal antibody light chains

Suzanne J. Gibson, Nicholas J. Bond, Stephen Milne, +6

Biotechnology and Bioengineering

A platform for context-specific genetic engineering of recombinant protein production by CHO cells

Joseph A. Cartwright, Claire L. Arnall, Yash D. Patel, +13

Journal of Biotechnology

EngineeringContext-specific Genetic EngineeringMedicineBiotechnologyGenetic Engineering +12

Control of Multigene Expression Stoichiometry in Mammalian Cells Using Synthetic Promoters

Yash D. Patel, Adam Brown, Jie Zhu, +4

ACS Synthetic Biology

EngineeringMultigene Expression StoichiometryGeneticsReporter GeneGene Regulatory Network +15

A novel hydrogen peroxide evolved CHO host can improve the expression of difficult to express bispecific antibodies

Rajesh K. Mistry, Emma J. Kelsall, Si Nga Sou, +6

Biotechnology and Bioengineering

Lipid PeroxidationHumoral ResponseImmunologyGlutathione ContentCholangiopathies +20

Autophagy and intracellular product degradation genes identified by systems biology analysis reduce aggregation of bispecific antibody in CHO cells

Mona Moradi Barzadd, Magnus Lundqvist, Claire Harris, +11

New Biotechnology

MitophagyImmunologyCell DeathImmunotherapyStable Chinese Hamster +24

Engineering the expression of an anti-interleukin-13 antibody through rational design and mutagenesis

Bojana Popovic, Suzanne J. Gibson, Tarik Senussi, +15

Protein Engineering Design and Selection

EngineeringImmunologyMolecular BiologyImmunologic MechanismTherapeutic Antibody +21