Concepedia

Pre-replication Complex Assembly

Pre-Replication Complex Assembly is a molecular process in which the origin recognition complex, Cdc6, Cdt1, and the minichromosome maintenance complex sequentially bind to replication origins during the G1 phase of the cell cycle, thereby licensing chromosomal sites for a single round of DNA replication by enabling the subsequent recruitment and activation of replication factors.

209

Publications

15.6K

Citations

898

Authors

320

Institutions

Publications per year

2017–2026

26

Variants

Pre-rc Assembly

Parents

Publications

209

Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis

Juan Méndez, Bruce Stillman · Molecular and Cellular Biology · 2000 · 934 citations · Full text

, , +17

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

Cécile Evrin, Pippa Clarke, Juergen Zech et al. · Proceedings of the National Academy of Sciences · 2009 · 551 citations

, , +17

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast

Shane Donovan, Janet Harwood, Lucy S. Drury et al. · Proceedings of the National Academy of Sciences · 1997 · 494 citations

, , +17

GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast

Yuko Takayama, Yoichiro Kamimura, Mariko Okawa et al. · Genes & Development · 2003 · 373 citations · Full text

, , +15

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in <i>cdc6</i> mutants

Chun Liang, Bruce Stillman · Genes & Development · 1997 · 362 citations · Full text

, , +17

1–5 of 209

Authors

898

  1. BS
    Bruce Stillman

    Cold Spring Harbor Laboratory, United States

    9 publications · 3K citations

    9

    h-index

  2. CL
    Chun Liang

    Hong Kong University of Science and Technology, Hong Kong SAR China

    8 publications · 559 citations

    8

    h-index

  3. JF
    John F.X. Diffley

    The Francis Crick Institute, United Kingdom

    8 publications · 1.6K citations

    8

    h-index

  4. SP
    Stephen P. Bell

    Massachusetts Institute of Technology, United States

    7 publications · 559 citations

    7

    h-index

  5. JC
    Johannes C. Walter

    Harvard University, United States

    7 publications · 776 citations

    7

    h-index

1–5 of 898

Institutions

320

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    12 h-index

    33 publications

    3.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    49 publications

    4.2K citations

  3. The University of Osaka

    Osaka, Japan

    10 h-index

    45 publications

    4.7K citations

  4. Hong Kong University of Science and Technology

    Hong Kong, Hong Kong

    10 h-index

    52 publications

    1.6K citations

  5. Harvard University

    Cambridge, United States

    10 h-index

    28 publications

    3K citations

  6. University of Hong Kong

    Pok Fu Lam, Hong Kong

    10 h-index

    51 publications

    2K citations

  7. Cold Spring Harbor Laboratory

    Cold Spring Harbor, United States

    9 h-index

    26 publications

    5.8K citations

  8. Institut de Génétique Humaine

    Montpellier, France

    8 h-index

    30 publications

    2.8K citations

1–8 of 320

Venues

  1. Journal of Biological Chemistry

    JBC · 22 publications · 984 citations

    17

    h-index

  2. Nucleic Acids Research

    16 publications · 611 citations

    15

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 2K citations

    14

    h-index

  4. Journal of Cell Science

    12 publications · 398 citations

    11

    h-index

  5. Cell Cycle

    12 publications · 245 citations

    11

    h-index

1–5