Concepedia

Polyreactivity Reduction

Polyreactivity Reduction is a methodological strategy in antibody engineering that specifically diminishes the capacity of antibodies to bind non-specifically to multiple structurally unrelated antigens while preserving target-specific affinity.

10

Publications

684

Citations

92

Authors

43

Institutions

Publications per year

2017–2026

6

Parents

Publications

10

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

Hugo Mouquet, Johannes F. Scheid, Michelle Krogsgaard et al. · Nature · 2010 · 420 citations

, , +14

Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

Michael R. Dyson, Edward W. Masters, Deividas Pazeraitis et al. · mAbs · 2020 · 67 citations · Full text

, , +17

An in silico method to assess antibody fragment polyreactivity

Edward P. Harvey, Jung-Eun Shin, Meredith A. Skiba et al. · Nature Communications · 2022 · 62 citations · Full text

, , +17

Sequence features of variable region determining physicochemical properties and polyreactivity of therapeutic antibodies

Maxime Lecerf, Alexia Kanyavuz, Sébastien Lacroix‐Desmazes et al. · Molecular Immunology · 2019 · 55 citations · Full text

, , +17

Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity

Catherine Y. Liu, Cory L. Ahonen, Michael E. Brown et al. · mAbs · 2023 · 19 citations · Full text

, , +17

1–5 of 10

Authors

92

  1. ML
    Maxime Lecerf

    Centre de Recherche des Cordeliers, France

    4 publications · 91 citations

    4

    h-index

  2. JD
    Jordan D. Dimitrov

    Inserm, France

    4 publications · 91 citations

    4

    h-index

  3. SL
    Sébastien Lacroix‐Desmazes

    Inserm, France

    3 publications · 76 citations

    3

    h-index

  4. AK
    Alexia Kanyavuz

    Inserm, France

    2 publications · 70 citations

    2

    h-index

  5. SV
    Srini V. Kaveri

    Inserm, France

    2 publications · 21 citations

    2

    h-index

1–5 of 92

Institutions

43

  1. Inserm

    Paris, France

    4 h-index

    21 publications

    418 citations

  2. Université Paris Cité

    Paris, France

    4 h-index

    20 publications

    403 citations

  3. Sorbonne Université

    Paris, France

    4 h-index

    23 publications

    440 citations

  4. Centre de Recherche des Cordeliers

    Paris, France

    4 h-index

    22 publications

    429 citations

  5. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    2 h-index

    14 publications

    563 citations

  6. National Institutes of Health

    Bethesda, United States

    2 h-index

    14 publications

    563 citations

  7. Harvard University

    Cambridge, United States

    2 h-index

    12 publications

    1.5K citations

  8. Boston VA Research Institute

    Boston, United States

    1 h-index

    6 publications

    372 citations

1–8 of 43

Venues

  1. Molecular Immunology

    2 publications · 66 citations

    2

    h-index

  2. mAbs

    2 publications · 86 citations

    2

    h-index

  3. Nature

    1 publications · 420 citations

    1

    h-index

  4. Nature Communications

    1 publications · 62 citations

    1

    h-index

  5. Protein Science

    PS · 1 publications · 11 citations

    1

    h-index

1–5