Concepedia

Polyketide Precursor Engineering

Polyketide Precursor Engineering is a biochemical engineering approach that specifically designs and optimizes the metabolic pathways and enzymatic machinery responsible for generating polyketide backbone precursors in microbial host systems to enhance the yield, diversity, or structural specificity of polyketide natural products.

87

Publications

4.9K

Citations

403

Authors

123

Institutions

Publications per year

2017–2026

14

Parents

Publications

87

Chapter 17 Bacterial Fatty Acid Synthesis and its Relationships with Polyketide Synthetic Pathways

John E. Cronan, Jacob Thomas · Methods in enzymology on CD-ROM/Methods in enzymology · 2009 · 307 citations · Full text

, , +16

A new pathway for polyketide synthesis in microorganisms

Nobutaka Funa, Yasuo Ohnishi, Isao Fujii et al. · Nature · 1999 · 297 citations

, , +13

Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase

John R. Jacobsen, C. Richard Hutchinson, David E. Cane et al. · Science · 1997 · 259 citations

, , +17

Rewiring <i>Yarrowia lipolytica</i> toward triacetic acid lactone for materials generation

Kelly A. Markham, Claire M. Palmer, Malgorzata Chwatko et al. · Proceedings of the National Academy of Sciences · 2018 · 195 citations · Full text

, , +16

Engineering 4-coumaroyl-CoA derived polyketide production in Yarrowia lipolytica through a β-oxidation mediated strategy

Claire M. Palmer, Kelly K. Miller, Ankim Nguyen et al. · Metabolic Engineering · 2019 · 184 citations

, , +12

1–5 of 87

Authors

403

  1. CK
    Chaitan Khosla

    Stanford University, United States

    12 publications · 929 citations

    11

    h-index

  2. DA
    David A. Hopwood

    John Innes Centre, United Kingdom

    5 publications · 557 citations

    5

    h-index

  3. BA
    Blaine A. Pfeifer

    University at Buffalo, State University of New York, United States

    5 publications · 111 citations

    5

    h-index

  4. RM
    Robert McDaniel

    Stanford University, United States

    5 publications · 412 citations

    5

    h-index

  5. CR
    C. Richard Hutchinson

    University of Wisconsin–Madison, United States

    4 publications · 555 citations

    4

    h-index

1–5 of 403

Institutions

123

  1. Stanford University

    Stanford, United States

    8 h-index

    23 publications

    1.9K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    5 h-index

    25 publications

    1.4K citations

  3. Tufts University

    Medford, United States

    4 h-index

    15 publications

    289 citations

  4. National University of Rosario

    Rosario, Argentina

    4 h-index

    10 publications

    279 citations

  5. Brown University

    Providence, United States

    3 h-index

    11 publications

    1.5K citations

  6. Consejo Nacional de Investigaciones Científicas y Técnicas

    Buenos Aires, Argentina

    3 h-index

    9 publications

    258 citations

  7. East China University of Science and Technology

    Shanghai, China

    3 h-index

    4 publications

    79 citations

  8. The University of Texas at Austin

    Austin, United States

    3 h-index

    16 publications

    2.9K citations

1–8 of 123

Venues

  1. Chemistry & Biology

    8 publications · 624 citations

    8

    h-index

  2. Journal of the American Chemical Society

    JACS · 6 publications · 473 citations

    6

    h-index

  3. Metabolic Engineering

    5 publications · 356 citations

    5

    h-index

  4. Applied Microbiology and Biotechnology

    5 publications · 144 citations

    5

    h-index

  5. Organic Letters

    OL · 5 publications · 174 citations

    5

    h-index

1–5