Concepedia

Point Mutation Induction

Point Mutation Induction is a mutagenic process in which a single nucleotide base in a DNA sequence is altered, substituted, inserted, or deleted through chemical, physical, or enzymatic agents, thereby introducing a site-specific genetic change that serves as a targeted mechanism for generating heritable point mutations in molecular biology and genetic research.

190

Publications

11K

Citations

912

Authors

291

Institutions

Publications per year

2017–2026

20

Parents

Publications

190

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

David B. Weiner, Jing Liu, Jeffrey A. Cohen et al. · Nature · 1989 · 427 citations

, , +15

Structural insights into conformational stability of both wild-type and mutant EZH2 receptor

Imlimaong Aier, Pritish Kumar Varadwaj, Utkarsh Raj · Scientific Reports · 2016 · 426 citations · Full text

, , +17

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid

Catherine Vilchèze, Feng Wang, Masayoshi Arai et al. · Nature Medicine · 2006 · 325 citations

, , +13

Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease

Jizhong Zou, Prashant Mali, Xiaosong Huang et al. · Blood · 2011 · 296 citations · Full text

, , +16

Mutations of the Rat Growth Hormone Promoter which Increase and Decrease Response to Thyroid Hormone Define a Consensus Thyroid Hormone Response Element

Gregory A. Brent, John W. Harney, Yoyi Chen et al. · Molecular Endocrinology · 1989 · 243 citations

, , +15

1–5 of 190

Authors

912

  1. JC
    Jill C. Pelling

    University of Nebraska Medical Center, United States

    4 publications · 240 citations

    4

    h-index

  2. DG
    Dezider Grünberger

    Columbia University, United States

    3 publications · 228 citations

    3

    h-index

  3. AM
    Adelaide M. Carothers

    Brigham and Women's Hospital, United States

    3 publications · 228 citations

    3

    h-index

  4. IK
    Igor Kovalchuk

    University of Lethbridge, Canada

    3 publications · 179 citations

    3

    h-index

  5. YM
    Yoshihiko Maehara

    Kyushu University, Japan

    2 publications · 76 citations

    2

    h-index

1–5 of 912

Institutions

291

  1. National Cancer Institute

    Bethesda, United States

    9 h-index

    26 publications

    2.3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    25 publications

    1.5K citations

  3. Kyushu University

    Fukuoka, Japan

    6 h-index

    34 publications

    1.5K citations

  4. Columbia University

    New York, United States

    5 h-index

    12 publications

    506 citations

  5. Heidelberg University

    Heidelberg, Germany

    5 h-index

    15 publications

    613 citations

  6. Stanford University

    Stanford, United States

    4 h-index

    24 publications

    3.5K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    16 publications

    3.1K citations

  8. University of Nebraska Medical Center

    Omaha, United States

    4 h-index

    20 publications

    1.1K citations

1–8 of 291

Venues

  1. PubMed

    Repository · 17 publications · 741 citations

    14

    h-index

  2. Carcinogenesis

    11 publications · 489 citations

    11

    h-index

  3. Journal of Virology

    JVI · 8 publications · 442 citations

    8

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 838 citations

    8

    h-index

  5. Environmental and Molecular Mutagenesis

    6 publications · 129 citations

    6

    h-index

1–5