Concepedia

Pharmacophore Model Refinement

Pharmacophore Model Refinement is a computational or methodological process that iteratively optimizes the structural and physicochemical features of a pharmacophore model to enhance its predictive accuracy and biological relevance in drug discovery.

279

Publications

10.4K

Citations

1.7K

Authors

441

Institutions

Publications per year

2017–2026

77

Parents

Publications

279

Methyllycaconitine: a selective probe for neuronal α‐bungarotoxin binding sites

Joanna M. Ward, Victor B. Cockcroft, G.G. Lunt et al. · FEBS Letters · 1990 · 223 citations · Full text

, , +15

Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors:  4-(Phenylamino)pyrazolo[3,4-<i>d</i>]pyrimidines

Peter Traxler, Guido Bold, Joerg Frei et al. · Journal of Medicinal Chemistry · 1997 · 205 citations · Full text

, , +17

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.

Paul A. Wender, C. M. CRIBBS, Konrad F. Koehler et al. · Proceedings of the National Academy of Sciences · 1988 · 201 citations · Full text

, , +17

The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies

Shin-Hua Lu, Josephine W. Wu, Hsuan‐Liang Liu et al. · Journal of Biomedical Science · 2011 · 196 citations · Full text

, , +17

Symplocamide A, a Potent Cytotoxin and Chymotrypsin Inhibitor from the Marine Cyanobacterium <i>Symploca</i> sp.

Roger G. Linington, Daniel Edwards, Cynthia F. Shuman et al. · Journal of Natural Products · 2007 · 190 citations · Full text

, , +16

1–5 of 279

Authors

1.7K

  1. ZU
    Zaheer Ul‐Haq

    University of Karachi, Pakistan

    6 publications · 155 citations

    6

    h-index

  2. TL
    Tommy Liljefors

    Lund University, Sweden

    5 publications · 340 citations

    5

    h-index

  3. KW
    Keun Woo Lee

    Gyeongsang National University, South Korea

    5 publications · 189 citations

    5

    h-index

  4. EN
    Ettore Novellino

    University of Naples Federico II, Italy

    5 publications · 299 citations

    5

    h-index

  5. PT
    Peter Traxler

    Novartis (Switzerland), Switzerland

    4 publications · 409 citations

    4

    h-index

1–5 of 1.7K

Institutions

441

  1. China Pharmaceutical University

    Nanjing, China

    7 h-index

    43 publications

    957 citations

  2. Gyeongsang National University

    Jinju-si, South Korea

    6 h-index

    39 publications

    1.5K citations

  3. University of Karachi

    Karachi, Pakistan

    6 h-index

    19 publications

    603 citations

  4. Shanghai Institute of Materia Medica

    Pudong, China

    6 h-index

    27 publications

    1.5K citations

  5. International Center for Chemical and Biological Sciences

    Karachi, Pakistan

    5 h-index

    17 publications

    551 citations

  6. University of Perugia

    Perugia, Italy

    5 h-index

    10 publications

    363 citations

  7. Chinese Academy of Sciences

    Beijing, China

    5 h-index

    18 publications

    890 citations

  8. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    5 h-index

    53 publications

    2.2K citations

1–8 of 441

Venues

  1. Journal of Medicinal Chemistry

    54 publications · 3.4K citations

    36

    h-index

  2. Journal of Chemical Information and Modeling

    JCIM · 15 publications · 563 citations

    14

    h-index

  3. Journal of Biomolecular Structure and Dynamics

    11 publications · 284 citations

    11

    h-index

  4. Chemical Biology & Drug Design

    10 publications · 211 citations

    10

    h-index

  5. European Journal of Medicinal Chemistry

    10 publications · 208 citations

    10

    h-index

1–5