Concepedia

Pharmacokinetic Selectivity

Pharmacokinetic Selectivity is a pharmacological property that refers to the differential distribution, metabolism, and elimination of a drug among distinct tissues or organs, enabling preferential exposure in target over non-target sites through inherent differences in absorption, protein binding, transport mechanisms, or clearance rates.

56

Publications

2K

Citations

486

Authors

113

Institutions

Publications per year

2017–2026

16

Parents

Publications

56

(−)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic Acid [(−)DRF 2725]:  A Dual PPAR Agonist with Potent Antihyperglycemic and Lipid Modulating Activity

Braj B. Lohray, Vidya Bhushan Lohray, Ashok C. Bajji et al. · Journal of Medicinal Chemistry · 2001 · 136 citations

, , +15

EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity

John E. Campbell, Kevin W. Kuntz, Sarah K. Knutson et al. · ACS Medicinal Chemistry Letters · 2015 · 129 citations · Full text

, , +11

Clinical pharmacokinetics of doxorubicin in combination with GF120918, a potent inhibitor of MDR1 P-glycoprotein

Alex Sparreboom, André Planting, Roxanne C. Jewell et al. · Anti-Cancer Drugs · 1999 · 95 citations

, , +14

Pharmacokinetics, Absorption and Tissue Distribution of Tanshinone IIA Solid Dispersion

Haiping Hao, Guangji Wang, Nan Cui et al. · Planta Medica · 2006 · 77 citations

, , +13

Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study

Su Young Jung, Sun-Jin Hwang, Jeffery M. Clarke et al. · Investigational New Drugs · 2019 · 76 citations

, , +13

1–5 of 56

Authors

486

  1. TC
    Theodor Chitlaru

    Israel Institute for Biological Research, Israel

    2 publications · 42 citations

    2

    h-index

  2. AS
    Avigdor Shafferman

    Israel Institute for Biological Research, Israel

    2 publications · 42 citations

    2

    h-index

  3. CK
    Chanoch Kronman

    Israel Institute for Biological Research, Israel

    2 publications · 42 citations

    2

    h-index

  4. BV
    Baruch Velan

    Israel Institute for Biological Research, Israel

    2 publications · 42 citations

    2

    h-index

  5. CC
    Changyi Cui

    Shandong University, China

    1 publications · 21 citations

    1

    h-index

1–5 of 486

Institutions

113

  1. China Pharmaceutical University

    Nanjing, China

    4 h-index

    31 publications

    1.1K citations

  2. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    3 h-index

    37 publications

    2K citations

  3. Kyoto Pharmaceutical University

    Kyoto, Japan

    2 h-index

    6 publications

    127 citations

  4. Israel Institute for Biological Research

    Ness Ziona, Israel

    2 h-index

    8 publications

    168 citations

  5. Molecular Biology Consortium

    Chicago, United States

    1 h-index

    1 publications

    16 citations

  6. Chongqing University

    Chongqing, China

    1 h-index

    3 publications

    42 citations

  7. Indian Institute of Technology Kharagpur

    Kharagpur, India

    1 h-index

    2 publications

    36 citations

  8. Ebara (Japan)

    Tokyo, Japan

    1 h-index

    3 publications

    48 citations

1–8 of 113

Venues

  1. Journal of Medicinal Chemistry

    8 publications · 390 citations

    8

    h-index

  2. PubMed

    Repository · 4 publications · 110 citations

    4

    h-index

  3. PLoS ONE

    2 publications · 69 citations

    2

    h-index

  4. Biochemical Journal

    BJ · 2 publications · 42 citations

    2

    h-index

  5. ACS Medicinal Chemistry Letters

    2 publications · 144 citations

    2

    h-index

1–5