Concepedia

Ph Partitioning

pH Partitioning is a physiological mechanism in the excretion of xenobiotics whereby the differential distribution of weak acids or bases across biological membranes is determined by the gradient of pH and the compound's pKa, influencing its ionization state and membrane permeability.

22

Publications

1.3K

Citations

75

Authors

34

Institutions

Publications per year

2017–2026

6

Variants

Ph Partitioning TheoryPh-partition Hypothesis

Parents

Publications

22

pH-Dependent partitioning in room temperature ionic liquids

Ann E. Visser, Richard P. Swatloski, Robin D. Rogers · Green Chemistry · 2000 · 279 citations

, , +7

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Fridén, Fredrik Bergström, Hong Wan et al. · Drug Metabolism and Disposition · 2010 · 183 citations

, , +17

pH-Partition Behavior of Tetracyclines

John L. Colaizzi, Paul R. Klink · Journal of Pharmaceutical Sciences · 1969 · 164 citations

, , +5

Relationship between caffeine concentrations in plasma and saliva

Ester Zylber‐Katz, L. Granit, Micha Levy · Clinical Pharmacology & Therapeutics · 1984 · 88 citations

, , +13

The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells

L.E. Gerweck, Sergey V. Kozin, Susan Jill Stocks · British Journal of Cancer · 1999 · 83 citations · Full text

, , +16

1–5 of 22

Authors

75

  1. VD
    Vesselin Diev

    Williams (United States), United States

    1 publications · 20 citations

    1

    h-index

  2. KS
    K.‐J. Schaper

    Research Center Borstel - Leibniz Lung Center, Germany

    1 publications · 22 citations

    1

    h-index

  3. DF
    Douglas Fox

    University of California, Berkeley, United States

    1 publications · 14 citations

    1

    h-index

  4. VF
    Victor F. Smolen

    Purdue University West Lafayette, United States

    1 publications · 16 citations

    1

    h-index

  5. OA
    Oleg A. Raevsky

    Institute of Physiologically Active Compounds, Russia

    1 publications · 22 citations

    1

    h-index

1–5 of 75

Institutions

34

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    1 h-index

    1 publications

    14 citations

  2. Agroscope

    Bern, Switzerland

    1 h-index

    2 publications

    136 citations

  3. Purdue University West Lafayette

    West Lafayette, United States

    1 h-index

    1 publications

    16 citations

  4. Uppsala University

    Uppsala, Sweden

    1 h-index

    1 publications

    183 citations

  5. Sapienza University of Rome

    Rome, Italy

    1 h-index

    2 publications

    132 citations

  6. University of California, Berkeley

    Berkeley, United States

    1 h-index

    4 publications

    56 citations

  7. Arizona State University

    Tempe, United States

    1 h-index

    1 publications

    66 citations

  8. Inimex Pharmaceuticals (Canada)

    Burnaby, Canada

    1 h-index

    1 publications

    43 citations

1–8 of 34

Venues

  1. Pharmaceutical Research

    2 publications · 45 citations

    2

    h-index

  2. Drug Metabolism and Disposition

    2 publications · 203 citations

    2

    h-index

  3. Journal of Pharmaceutical Sciences

    2 publications · 180 citations

    2

    h-index

  4. Antimicrobial Agents and Chemotherapy

    AAC · 1 publications · 14 citations

    1

    h-index

  5. Clinical Pharmacology & Therapeutics

    CPT · 1 publications · 88 citations

    1

    h-index

1–5