The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

Peter Vaupel, F. Kallinowski, Paul Okunieff · PubMed · 1989 · 3.4K citations

Tumor Innervation, Biological Microenvironments, Pathology +20

Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.

L.E. Gerweck, Koushik Seetharaman · PubMed · 1996 · 1.1K citations

Pathology, Cancer Biology, Cellular Ph Gradient +17

CALCULATION OF INTRACELLULAR pH FROM THE DISTRIBUTION OF 5,5-DIMETHYL-2,4-OXAZOLIDINEDIONE (DMO). APPLICATION TO SKELETAL MUSCLE OF THE DOG*

William J. Waddell, Thomas Butler · Journal of Clinical Investigation · 1959 · 684 citations · Full text

Bioelectrochemistry, Cellular Physiology, Ion Process +25

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

Thomas R. Triton, Gene K. Yee · Science · 1982 · 572 citations

Antiparasitic Agent, Antibiotic Adjuvant, Pathology +17

Transport and binding of daunorubicin, adriamycin, and rubidazone in ehrlich ascites tumour cells

Torben Skovsgaard · Biochemical Pharmacology · 1977 · 168 citations

Ehrlich Ascites, Biochemistry, Medicine +7