Concepedia

Perturbation Response Modeling

Perturbation Response Modeling is a computational framework that characterizes the dynamic effects of targeted biological or environmental disruptions on disease-related molecular systems to infer causal mechanisms and predict therapeutic outcomes.

29

Publications

1.3K

Citations

108

Authors

53

Institutions

Publications per year

2017–2026

15

Parents

Publications

29

Perturbation-Response Scanning Reveals Ligand Entry-Exit Mechanisms of Ferric Binding Protein

Canan Atılgan, Ali Rana Atılgan · PLoS Computational Biology · 2009 · 249 citations · Full text

, , +17

MD-TASK: a software suite for analyzing molecular dynamics trajectories

David K. Brown, David L. Penkler, Olivier Sheik Amamuddy et al. · Bioinformatics · 2017 · 221 citations · Full text

, , +15

CellBox: Interpretable Machine Learning for Perturbation Biology with Application to the Design of Cancer Combination Therapy

Bo Yuan, Ciyue Shen, Augustin Luna et al. · Cell Systems · 2020 · 130 citations · Full text

, , +13

Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

Anil Korkut, Weiqing Wang, Emek Demir et al. · eLife · 2015 · 120 citations · Full text

, , +17

Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery

Xiaoning Qi, Lianhe Zhao, Chenyu Tian et al. · Nature Communications · 2024 · 58 citations · Full text

, , +14

1–5 of 29

Authors

108

  1. GM
    Gennady M. Verkhivker

    Chapman University, United States

    4 publications · 69 citations

    4

    h-index

  2. AR
    Ali Rana Atılgan

    Sabancı Üniversitesi, Türkiye

    4 publications · 527 citations

    4

    h-index

  3. CA
    Canan Atılgan

    Sabancı Üniversitesi, Türkiye

    3 publications · 490 citations

    3

    h-index

  4. CS
    Chris Sander

    Memorial Sloan Kettering Cancer Center, United States

    3 publications · 274 citations

    3

    h-index

  5. KS
    Kumar Selvarajoo

    Keio University, Japan

    3 publications · 74 citations

    3

    h-index

1–5 of 108

Institutions

53

  1. Sabancı Üniversitesi

    Istanbul, Türkiye

    4 h-index

    9 publications

    1.1K citations

  2. Chapman University

    Orange, United States

    4 h-index

    4 publications

    69 citations

  3. Keio University

    Tokyo, Japan

    3 h-index

    12 publications

    291 citations

  4. Broad Institute

    Cambridge, United States

    2 h-index

    6 publications

    674 citations

  5. Harvard University

    Cambridge, United States

    2 h-index

    6 publications

    674 citations

  6. University of Michigan

    Ann Arbor, United States

    2 h-index

    6 publications

    116 citations

  7. Soochow University

    Suzhou, China

    2 h-index

    7 publications

    156 citations

  8. Keio University Shonan Fujisawa

    Fujisawa, Japan

    2 h-index

    9 publications

    225 citations

1–8 of 53

Venues

  1. Journal of Thermal Stresses

    2 publications · 62 citations

    2

    h-index

  2. Scientific Reports

    2 publications · 47 citations

    2

    h-index

  3. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 41 citations

    2

    h-index

  4. 1

    h-index

  5. Molecular Systems Biology

    1 publications · 17 citations

    1

    h-index

1–5