An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

Baoxue Quan, Huiping Shuai, Anjie Xia, +25

Nature Microbiology

MedicineImmunologyAntiviral Drug DevelopmentAntiviral TherapyVirology +8

Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor

Yueshan Li, Liting Zhang, Yifei Wang, +11

Nature Communications

Non-classical ferroptosis inhibition by a small molecule targeting PHB2

Wei Yang, Bo Mu, Jing You, +13

Nature Communications

Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery

Xiaoning Qi, Lianhe Zhao, Chenyu Tian, +7

Nature Communications

Tertiary lymphoid structure patterns predicted anti-PD1 therapeutic responses in gastric cancer

Quan Jiang, Chenyu Tian, Hao Wu, +5

Chinese Journal of Cancer Research

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO)

Shulei Pan, Yangli Zhou, Qiusheng Wang, +7

European Journal of Medicinal Chemistry

Potent Dual InhibitorsCombinatorial ChemistryMedicinal ChemistryBiochemistryNatural Sciences +9

Structural Optimization and Structure–Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6<i>H</i>-pyrimido[5,4-<i>b</i>][1,4]oxazin-7(8<i>H</i>)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

Shulei Pan, Liting Zhang, Xinling Luo, +13

Journal of Medicinal Chemistry

Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model

Chenyu Tian, Guo Zhang, Ziyi Xia, +3

European Journal of Medicinal Chemistry

Medicinal ChemistryPharmacological StudyMedicinePsoriatic ArthritisPharmacological Agent +7

Discovery of 3,4-Dihydrobenzo[<i>f</i>][1,4]oxazepin-5(2<i>H</i>)-one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects

Yueshan Li, Liting Zhang, Ruicheng Yang, +9

Journal of Medicinal Chemistry

Demethylation of the <i>SFRP4</i> Promoter Drives Gastric Cancer Progression via the Wnt Pathway

Haojie Li, Junjie Zhao, Jie Sun, +8

Molecular Cancer Research