Concepedia

Peripheral Tolerance Breakdown

Peripheral Tolerance Breakdown is a pathogenic mechanism in autoimmune disease pathogenesis characterized by the failure of immune tolerance mechanisms in peripheral tissues, leading to the activation of self-reactive lymphocytes that escape central tolerance and initiate autoimmunity.

307

Publications

34.4K

Citations

1.8K

Authors

567

Institutions

Publications per year

2017–2026

55

Parents

Publications

307

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano et al. · The Journal of Immunology · 1995 · 5.5K citations

, , +17

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai et al. · The Journal of Experimental Medicine · 2000 · 5.2K citations · Full text

, , +17

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Vissia Viglietta, Clare Baecher‐Allan, Howard L. Weiner et al. · The Journal of Experimental Medicine · 2004 · 1.8K citations · Full text

, , +17

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

Julia A. Brown, David M. Dorfman, Fengrong Ma et al. · The Journal of Immunology · 2003 · 962 citations

, , +15

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

Tomohide Yamazaki, Hisaya Akiba, Hideyuki Iwai et al. · The Journal of Immunology · 2002 · 946 citations · Full text

, , +15

1–5 of 307

Authors

1.8K

  1. KS
    Kenneth S. K. Tung

    University of Virginia, United States

    4 publications · 98 citations

    4

    h-index

  2. MA
    Miyuki Azuma

    Tokyo Medical and Dental University, Japan

    4 publications · 1K citations

    4

    h-index

  3. BT
    Bruce Turpie

    Harvard University, United States

    3 publications · 141 citations

    3

    h-index

  4. WV
    Willem van Eden

    Utrecht University, Netherlands

    3 publications · 118 citations

    3

    h-index

  5. GJ
    Gordon J. Freeman

    Dana-Farber Cancer Institute, United States

    3 publications · 1.9K citations

    3

    h-index

1–5 of 1.8K

Institutions

567

  1. Harvard University

    Cambridge, United States

    16 h-index

    63 publications

    38.5K citations

  2. University of Pennsylvania

    Philadelphia, United States

    9 h-index

    49 publications

    2.5K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    23 publications

    2.5K citations

  4. Brigham and Women's Hospital

    Boston, United States

    6 h-index

    19 publications

    12.1K citations

  5. University of Virginia

    Charlottesville, United States

    6 h-index

    20 publications

    1.1K citations

  6. Tokyo Medical and Dental University

    Tokyo, Japan

    6 h-index

    15 publications

    3.9K citations

  7. Heidelberg University

    Heidelberg, Germany

    6 h-index

    22 publications

    1.6K citations

  8. Kyushu University

    Fukuoka, Japan

    5 h-index

    24 publications

    460 citations

1–8 of 567

Venues

  1. The Journal of Immunology

    JI · 63 publications · 9.9K citations

    36

    h-index

  2. The Journal of Experimental Medicine

    17 publications · 8.9K citations

    17

    h-index

  3. European Journal of Immunology

    EJI · 21 publications · 1.6K citations

    16

    h-index

  4. PubMed

    Repository · 15 publications · 657 citations

    12

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 1.4K citations

    11

    h-index

1–5