Concepedia

Peptide Complement Inhibitors

Peptide Complement Inhibitors is a class of therapeutic peptides that selectively modulate the activity of the complement system by targeting specific components or activation pathways, thereby distinguishing themselves from other complement inhibitory agents through their peptidic structure and mechanism of molecular interaction.

71

Publications

3K

Citations

328

Authors

101

Institutions

Publications per year

2017–2026

6

Parents

Publications

71

Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library

Arvind Sahu, Brian K. Kay, John D. Lambris · The Journal of Immunology · 1996 · 264 citations

, , +16

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Antonio M. Risitano, Daniel Ricklin, Yijun Huang et al. · Blood · 2014 · 195 citations · Full text

, , +11

Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition

B.J.C. Janssen, Els F. Halff, John D. Lambris et al. · Journal of Biological Chemistry · 2007 · 129 citations · Full text

, , +15

Binding Kinetics, Structure-Activity Relationship, and Biotransformation of the Complement Inhibitor Compstatin

Arvind Sahu, Athena M. Soulika, Dimitrios Morikis et al. · The Journal of Immunology · 2000 · 111 citations · Full text

, , +16

Hydrophobic Effect and Hydrogen Bonds Account for the Improved Activity of a Complement Inhibitor, Compstatin

Madan Katragadda, Paola Magotti, Georgia Sfyroera et al. · Journal of Medicinal Chemistry · 2006 · 110 citations · Full text

, , +17

1–5 of 71

Authors

328

  1. JD
    John D. Lambris

    University of Pennsylvania, United States

    14 publications · 1.3K citations

    13

    h-index

  2. DM
    Dimitrios Morikis

    University of California, Riverside, United States

    11 publications · 480 citations

    11

    h-index

  3. NK
    Neel K. Krishna

    Eastern Virginia Medical School, United States

    8 publications · 251 citations

    8

    h-index

  4. KM
    Kenji M. Cunnion

    Eastern Virginia Medical School, United States

    8 publications · 251 citations

    8

    h-index

  5. PS
    Pamela S. Hair

    Eastern Virginia Medical School, United States

    8 publications · 251 citations

    8

    h-index

1–5 of 328

Institutions

101

  1. University of Pennsylvania

    Philadelphia, United States

    13 h-index

    51 publications

    5K citations

  2. University of California, Riverside

    Riverside, United States

    9 h-index

    30 publications

    806 citations

  3. Children's Specialty Group

    Norfolk, United States

    7 h-index

    14 publications

    388 citations

  4. Eastern Virginia Medical School

    Norfolk, United States

    7 h-index

    39 publications

    1.4K citations

  5. Princeton University

    Princeton, United States

    6 h-index

    18 publications

    483 citations

  6. University of Cyprus

    Nicosia, Cyprus

    5 h-index

    17 publications

    504 citations

  7. Children's Hospital of The King's Daughters

    Norfolk, United States

    5 h-index

    15 publications

    287 citations

  8. Nagoya City University

    Nagoya, Japan

    4 h-index

    16 publications

    319 citations

1–8 of 101

Venues

  1. The Journal of Immunology

    JI · 13 publications · 833 citations

    12

    h-index

  2. Molecular Immunology

    8 publications · 304 citations

    8

    h-index

  3. Journal of Medicinal Chemistry

    4 publications · 174 citations

    4

    h-index

  4. Chemical Biology & Drug Design

    3 publications · 64 citations

    3

    h-index

  5. PLoS ONE

    3 publications · 70 citations

    3

    h-index

1–5