Concepedia

Pax5-mediated Lineage Commitment

PAX5-Mediated Lineage Commitment is a molecular regulatory mechanism in hematopoietic development wherein the transcription factor PAX5 directs the irreversible specification of common lymphoid progenitors toward the B cell lineage by activating B cell-specific gene expression programs and simultaneously repressing alternative lineage potentials.

118

Publications

11.8K

Citations

760

Authors

253

Institutions

Publications per year

2017–2026

14

Parents

Publications

118

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

Stephen L. Nutt, Barry Heavey, Antonius Rolink et al. · Nature · 1999 · 1.2K citations

, , +14

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

Pavel Urbánek · Cell · 1994 · 799 citations

, , +16

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

Zhaohui Gu, Michelle L. Churchman, Kathryn G. Roberts et al. · Nature Genetics · 2019 · 617 citations · Full text

, , +14

Blimp-1-Dependent Repression of <i>Pax-5</i> Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells

Kuo‐I Lin, Cristina Angelin‐Duclos, Tracy C. Kuo et al. · Molecular and Cellular Biology · 2002 · 439 citations · Full text

, , +15

CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity

Elad Jacoby, Sang M. Nguyen, Thomas J. Fountaine et al. · Nature Communications · 2016 · 427 citations · Full text

, , +17

1–5 of 118

Authors

760

  1. MB
    Meinrad Busslinger

    Research Institute of Molecular Pathology, Austria

    20 publications · 4.2K citations

    19

    h-index

  2. SL
    Stephen L. Nutt

    Walter and Eliza Hall Institute of Medical Research, Australia

    9 publications · 2.4K citations

    9

    h-index

  3. AR
    Antonius Rolink

    University of Basel, Switzerland

    9 publications · 2K citations

    9

    h-index

  4. MS
    Mikael Sigvardsson

    Lund University, Sweden

    8 publications · 446 citations

    8

    h-index

  5. HT
    Hiromi Tagoh

    Research Institute of Molecular Pathology, Austria

    6 publications · 816 citations

    6

    h-index

1–5 of 760

Institutions

253

  1. Research Institute of Molecular Pathology

    Vienna, Austria

    21 h-index

    87 publications

    19.3K citations

  2. Vienna Biocenter

    Vienna, Austria

    10 h-index

    55 publications

    11.6K citations

  3. University of Pennsylvania

    Philadelphia, United States

    7 h-index

    23 publications

    3K citations

  4. Lund University

    Lund, Sweden

    6 h-index

    37 publications

    2.9K citations

  5. Linköping University

    Linköping, Sweden

    5 h-index

    17 publications

    737 citations

  6. Columbia University

    New York, United States

    5 h-index

    28 publications

    4.7K citations

  7. Inserm

    Paris, France

    5 h-index

    32 publications

    1.7K citations

  8. University of Leeds

    Leeds, United Kingdom

    4 h-index

    9 publications

    932 citations

1–8 of 253

Venues

  1. Blood

    23 publications · 1.4K citations

    19

    h-index

  2. The Journal of Immunology

    JI · 13 publications · 520 citations

    13

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 345 citations

    8

    h-index

  4. Immunity

    5 publications · 1.1K citations

    5

    h-index

  5. The Journal of Experimental Medicine

    5 publications · 505 citations

    5

    h-index

1–5