Concepedia

Pairing Heavy Chains

Pairing Heavy Chains is a methodological framework in antibody discovery that enables the precise co-selection and recombinant association of heavy chain proteins with their cognate light chains to reconstruct fully functional, antigen-specific antibodies.

11

Publications

1.3K

Citations

64

Authors

21

Institutions

Publications per year

2017–2026

3

Parents

Publications

11

In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire

Brandon J. DeKosky, Takaaki Kojima, Alexa Rodin et al. · Nature Medicine · 2014 · 379 citations

, , +13

Analysis of Heavy and Light Chain Pairings Indicates that Receptor Editing Shapes the Human Antibody Repertoire

Ruud M. T. de Wildt, René M.A. Hoet, Walther J. van Venrooij et al. · Journal of Molecular Biology · 1999 · 220 citations

, , +14

Three‐dimensional structure determination of an anti‐2‐phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response.

Pedro M. Alzari, S. Spinelli, Roy A. Mariuzza et al. · The EMBO Journal · 1990 · 143 citations · Full text

, , +17

Isolation of Human Antibody Repertoires with Preservation of the Natural Heavy and Light Chain Pairing

Per‐Johan Meijer, Peter S. Andersen, Margit Haahr Hansen et al. · Journal of Molecular Biology · 2006 · 125 citations

, , +16

Intrachain disulfide bond in the core hinge region of human IgG4

James W. Bloom, Melanie S. Madanat, David Marriott et al. · Protein Science · 1997 · 122 citations · Full text

, , +12

1–5 of 11

Authors

64

  1. RM
    Ruud M. T. de Wildt

    Radboud University Nijmegen, Netherlands

    2 publications · 265 citations

    2

    h-index

  2. GW
    Greg Winter

    MRC Laboratory of Molecular Biology, United Kingdom

    2 publications · 265 citations

    2

    h-index

  3. WJ
    Walther J. van Venrooij

    Radboud University Nijmegen, Netherlands

    2 publications · 265 citations

    2

    h-index

  4. JC
    Julia Coronella

    Poseida Therapeutics (United States), United States

    1 publications · 45 citations

    1

    h-index

  5. NG
    Natalia Gasilova

    École Polytechnique Fédérale de Lausanne, Switzerland

    1 publications · 60 citations

    1

    h-index

1–5 of 64

Institutions

21

  1. Radboud University Nijmegen

    Nijmegen, The Netherlands

    2 h-index

    8 publications

    1.2K citations

  2. University of Michigan

    Ann Arbor, United States

    1 h-index

    3 publications

    39 citations

  3. National Institutes of Health

    Bethesda, United States

    1 h-index

    1 publications

    94 citations

  4. Bayer (United States)

    Whippany, United States

    1 h-index

    5 publications

    610 citations

  5. Spectroswiss (Switzerland)

    Lausanne, Switzerland

    1 h-index

    3 publications

    180 citations

  6. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    1 h-index

    8 publications

    480 citations

  7. Center of Immunology Pierre Fabre

    Saint-Julien-en-Genevois, France

    1 h-index

    1 publications

    60 citations

  8. Institute of Energy Problems of Chemical Physics

    Moscow, Russia

    1 h-index

    2 publications

    120 citations

1–8 of 21

Venues

  1. Analytical Chemistry

    2 publications · 73 citations

    2

    h-index

  2. Nucleic Acids Research

    2 publications · 72 citations

    2

    h-index

  3. Journal of Molecular Biology

    JMB · 2 publications · 345 citations

    2

    h-index

  4. Protein Science

    PS · 1 publications · 122 citations

    1

    h-index

  5. Nature Medicine

    1 publications · 379 citations

    1

    h-index

1–5