Orthology-Based Interface Comparison is a computational method that identifies and analyzes structurally conserved protein-protein interaction interfaces by aligning homologous proteins across species under the assumption of shared evolutionary descent, thereby distinguishing functionally conserved interaction mechanisms from lineage-specific adaptations.
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Juan Rodriguez-Rivas, Simone Marsili, David Juan et al. · Proceedings of the National Academy of Sciences · 2016 · 40 citations · Full text
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- JDJason D. Hughes
Merck & Co., Inc., Rahway, NJ, USA (United States), United States
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Boston University
Boston, United States
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344 citations
University of Wisconsin–Madison
Madison, United States
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176 citations
Scripps Research Institute
San Diego, United States
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132 citations
Pfizer (United States)
New York, United States
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Howard Hughes Medical Institute
Chevy Chase, United States
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44 citations
Spanish National Cancer Research Centre
Madrid, Spain
1 h-index
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160 citations
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JBC · 1 publications · 44 citations
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PNAS · 1 publications · 40 citations
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