Concepedia

Optic Atrophy 1

Optic Atrophy 1 is a dynamin-related GTPase protein that functions as a key mediator of mitochondrial outer membrane fusion, distinguishing it from other mitochondrial dynamics proteins by its specific localization to the mitochondrial outer membrane and its essential role in maintaining mitochondrial network integrity.

504

Publications

40.2K

Citations

3.3K

Authors

946

Institutions

Publications per year

2017–2026

190

Variants

Opa1

Parents

Publications

504

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

Cécile Delettre, Guy Lenaers, Jean‐Michel Griffoin et al. · Nature Genetics · 2000 · 1.4K citations

, , +13

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

Christiane Alexander, Marcela Votruba, Ulrike E. A. Pesch et al. · Nature Genetics · 2000 · 1.3K citations

, , +9

OPA1 requires mitofusin 1 to promote mitochondrial fusion

Sara Cipolat, Olga Martins de Brito, Barbara Dal Zilio et al. · Proceedings of the National Academy of Sciences · 2004 · 1.3K citations · Full text

, , +16

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

Aurélien Olichon, Laurent Baricault, Nicole Gas et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

, , +17

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

Maria Mańczak, Marcus J. Calkins, P. Hemachandra Reddy · Human Molecular Genetics · 2011 · 813 citations · Full text

, , +17

1–5 of 504

Authors

3.3K

  1. GL
    Guy Lenaers

    Inserm, France

    24 publications · 5K citations

    21

    h-index

  2. PR
    Pascal Reynier

    Inserm, France

    21 publications · 2.4K citations

    19

    h-index

  3. LS
    Luca Scorrano

    Veneto Institute of Molecular Medicine, Italy

    19 publications · 3.9K citations

    19

    h-index

  4. BW
    Bernd Wissinger

    STZ eyetrial, Germany

    16 publications · 3K citations

    16

    h-index

  5. PA
    Patrizia Amati‐Bonneau

    Inserm, France

    17 publications · 2.2K citations

    16

    h-index

1–5 of 3.3K

Institutions

946

  1. Inserm

    Paris, France

    29 h-index

    339 publications

    52.8K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    22 h-index

    154 publications

    19.3K citations

  3. Veneto Institute of Molecular Medicine

    Padua, Italy

    19 h-index

    65 publications

    18.2K citations

  4. University College London

    London, United Kingdom

    18 h-index

    75 publications

    9.8K citations

  5. Université d'Angers

    Angers, France

    17 h-index

    118 publications

    6.2K citations

  6. University of Padua

    Padua, Italy

    17 h-index

    90 publications

    17.8K citations

  7. Centre Hospitalier Universitaire d'Angers

    Angers, France

    15 h-index

    128 publications

    28.9K citations

  8. University of Bologna

    Bologna, Italy

    15 h-index

    106 publications

    27.6K citations

1–8 of 946

Venues

  1. Human Molecular Genetics

    19 publications · 3.7K citations

    18

    h-index

  2. PubMed

    Repository · 26 publications · 888 citations

    18

    h-index

  3. American Journal of Ophthalmology

    15 publications · 877 citations

    14

    h-index

  4. Investigative Ophthalmology & Visual Science

    IOVS · 14 publications · 705 citations

    12

    h-index

  5. Journal of Biological Chemistry

    JBC · 11 publications · 3.4K citations

    11

    h-index

1–5