Guy Lenaers

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

Cécile Delettre, Guy Lenaers, Jean‐Michel Griffoin et al. · Nature Genetics · 2000 · 1.4K citations

Neurodegenerative Diseases, Mitochondrial Function, Ophthalmology +9

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

Aurélien Olichon, Laurent Baricault, Nicole Gas et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

Mitochondrial Inner Membrane, Apoptosis, Molecular Biology +16

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes

Patrizia Amati‐Bonneau, Maria Lucia Valentino, Pascal Reynier et al. · Brain · 2007 · 510 citations · Full text

Opa1 Gene, Genome Instability, Mitochondrial Biogenesis +15

Multi-system neurological disease is common in patients with OPA1 mutations

Patrick Yu‐Wai‐Man, Philip G. Griffiths, Gráinne S. Gorman et al. · Brain · 2010 · 437 citations · Full text

The human dynamin‐related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter‐membrane space

Aurélien Olichon, Laurent J. Emorine, Eric Descoins et al. · FEBS Letters · 2002 · 411 citations · Full text