Concepedia

Off-target Binding Mitigation

Off-Target Binding Mitigation is a methodological strategy in antibody specificity engineering that systematically reduces non-specific interactions between an engineered antibody and unintended molecular targets while preserving high-affinity binding to the intended antigen.

29

Publications

1.4K

Citations

261

Authors

92

Institutions

Publications per year

2017–2026

18

Parents

Publications

29

A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization

Esther Drent, Maria Themeli, Renée Poels et al. · Molecular Therapy · 2017 · 288 citations · Full text

, , +17

Tau positron emission tomography imaging in tauopathies: The added hurdle of off‐target binding

Laëtitia Lemoine, Antoine Leuzy, Konstantinos Chiotis et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 2018 · 143 citations · Full text

, , +17

Identification of selective cyclin-dependent kinase 2 inhibitor from the library of pyrrolone-fused benzosuberene compounds: an in silico exploration

Rahul Singh, Vijay Kumar Bhardwaj, Jatin Sharma et al. · Journal of Biomolecular Structure and Dynamics · 2021 · 127 citations · Full text

, , +15

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4

Daniela Bumbaca, Anne Wong, Elizabeth A. Drake et al. · mAbs · 2011 · 110 citations · Full text

, , +17

Cbl-independent degradation of Met: ways to avoid agonism of bivalent Met-targeting antibody

Ji Min Lee, Byoung‐Gie Kim, Sang Bae Lee et al. · Oncogene · 2012 · 74 citations

, , +14

1–5 of 29

Authors

261

  1. TP
    T.L. Poulos

    University of California, Irvine, United States

    3 publications · 99 citations

    3

    h-index

  2. MA
    Maris A. Cinelli

    Northwestern University, United States

    3 publications · 99 citations

    3

    h-index

  3. RB
    Richard B. Silverman

    Northwestern University, United States

    3 publications · 99 citations

    3

    h-index

  4. MU
    Mathias Uhlén

    KTH Royal Institute of Technology, Sweden

    2 publications · 36 citations

    2

    h-index

  5. GC
    Georges Chreifi

    University of California, Irvine, United States

    2 publications · 68 citations

    2

    h-index

1–5 of 261

Institutions

92

  1. Northwestern University

    Evanston, United States

    3 h-index

    10 publications

    310 citations

  2. Karolinska University Hospital

    Stockholm, Sweden

    3 h-index

    6 publications

    265 citations

  3. University of California, Irvine

    Irvine, United States

    3 h-index

    8 publications

    266 citations

  4. Karolinska Institutet

    Stockholm, Sweden

    3 h-index

    11 publications

    853 citations

  5. Charles University

    Prague, Czechia

    3 h-index

    3 publications

    74 citations

  6. Washington University in St. Louis

    St Louis, United States

    2 h-index

    3 publications

    64 citations

  7. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    2 h-index

    4 publications

    112 citations

  8. KTH Royal Institute of Technology

    Stockholm, Sweden

    2 h-index

    14 publications

    254 citations

1–8 of 92

Venues

  1. Journal of Medicinal Chemistry

    5 publications · 141 citations

    5

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 72 citations

    2

    h-index

  3. Nucleic Acids Research

    2 publications · 48 citations

    2

    h-index

  4. 1

    h-index

  5. Analytical Biochemistry

    1 publications · 58 citations

    1

    h-index

1–5