A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies

Gabriele Schaefer, Lauric Haber, Lisa Crocker, +20

Cancer Cell

Immunocytochemical TechniqueAllergyAutoimmune DiseaseImmunologyAntibody Screening +7

Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans

Marcella Yu, Darren L. Brown, Chae Reed, +6

mAbs

N-linked Mannose-5 GlycansImmunologyGlycobiologyImmunodominanceHomogeneous Antibodies +18

FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways

Ai-Luen Wu, Sally Coulter, Christopher Liddle, +5

PLoS ONE

Cell ProliferationCholangiopathiesFgf19 ProteinFibroblast Growth FactorMetabolic Signaling +17

Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

Ai-Luen Wu, Ganesh Kolumam, Scott Stawicki, +20

Science Translational Medicine

InflammationSignal TransductionGrowth HormoneBrown Adipose TissuesDiabetes +11

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

Bing Li, Devin B. Tesar, C. Andrew Boswell, +10

mAbs

Framework SelectionDrug TargetImmunocytochemical TechniqueImmunologyImmunodominance +23

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4

Daniela Bumbaca, Anne Wong, Elizabeth A. Drake, +6

mAbs

Immunocytochemical TechniqueImmunologyTherapeutic AntibodyImmunotherapyCancer Biology +16

Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1

Shilpa Keerthivasan, Yasin Şenbabaoğlu, Nadia Martinez-Martín, +17

Immunity

InflammationCytokineInflammatory Lung DiseaseHomeostatic FunctionsLung Inflammation +11

Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose

Amrita V. Kamath, Dan Lu, Priyanka Gupta, +8

Cancer Chemotherapy and Pharmacology

Efficacious Clinical DoseHuman PharmacokineticsMedicineImmunologyTherapeutic Efficacy +6

Generation of platelet activating factor (PAF) by a human lung epithelial cell line

Hassan Salari, Anne Wong

European Journal of Pharmacology

InflammationThrombopoiesisSignal TransductionInflammatory Lung DiseaseBlood Platelet +6

Engineering Upper Hinge Improves Stability and Effector Function of a Human IgG1

Boxu Yan, Daniel Boyd, Timothy Kaschak, +18

Journal of Biological Chemistry