Concepedia

Nonlinear Dose Proportionality

Nonlinear Dose Proportionality is a pharmacokinetic phenomenon in which the relationship between drug dose and systemic exposure deviates from direct proportionality due to capacity-limited processes such as enzyme saturation or dose-dependent changes in clearance.

8

Publications

185

Citations

34

Authors

15

Institutions

Publications per year

2017–2026

2

Parents

Publications

8

Dose Proportionality of Oral Etoricoxib, a Highly Selective Cyclooxygenase‐2 Inhibitor, in Healthy Volunteers

Nancy Agrawal, Arturo G. Porras, Catherine Z. Matthews et al. · The Journal of Clinical Pharmacology · 2001 · 60 citations

, , +14

Pharmacokinetics and system linearity of tea catechins in rat

Min Zhu, Y. Chen, R C Li · Xenobiotica · 2001 · 33 citations

, , +13

Multiple-dose pharmacokinetics confirm no accumulation and dose proportionality of the novel promotile drug tegaserod (HTF 919)

Silke Appel‐Dingemanse, Yulia Hirschberg, Stuart Osborne et al. · European Journal of Clinical Pharmacology · 2001 · 20 citations

, , +12

Population pharmacokinetics of the 11β‐hydroxysteroid dehydrogenase type 1 inhibitor ABT‐384 in healthy volunteers following single and multiple dose regimens

Guohua An, Wei Liu, David A. Katz et al. · Biopharmaceutics & Drug Disposition · 2014 · 17 citations

, , +9

Pharmacokinetics, Dose Proportionality, and Bioavailability of Bazedoxifene in Healthy Postmenopausal Women

William McKeand · Clinical Therapeutics · 2017 · 17 citations

, , +9

1–5 of 8

Authors

34

  1. DA
    David A. Katz

    AbbVie (United States), United States

    2 publications · 32 citations

    2

    h-index

  2. GA
    Guohua An

    University of Iowa, United States

    2 publications · 32 citations

    2

    h-index

  3. PD
    P. Dostert

    Nagoya Institute of Technology, Japan

    1 publications · 13 citations

    1

    h-index

  4. EW
    Eric Woolf

    United States Military Academy, United States

    1 publications · 60 citations

    1

    h-index

  5. MJ
    M.G. Jannuzzo

    Nerviano Medical Sciences, Italy

    1 publications · 13 citations

    1

    h-index

1–5 of 34

Institutions

15

  1. Translational Therapeutics (United States)

    Arlington, United States

    1 h-index

    2 publications

    30 citations

  2. Novartis (France)

    Rueil-Malmaison, France

    1 h-index

    1 publications

    20 citations

  3. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    1 h-index

    8 publications

    480 citations

  4. Chinese University of Hong Kong

    Hong Kong, Hong Kong

    1 h-index

    3 publications

    99 citations

  5. AbbVie (United States)

    North Chicago, United States

    1 h-index

    6 publications

    102 citations

  6. United States Military Academy

    West Point, United States

    1 h-index

    1 publications

    60 citations

  7. Research Triangle Park Foundation

    Durham, United States

    1 h-index

    1 publications

    10 citations

  8. Novartis (United States)

    New York, United States

    1 h-index

    2 publications

    40 citations

1–8 of 15

Venues

  1. The Journal of Clinical Pharmacology

    3 publications · 85 citations

    3

    h-index

  2. Biopharmaceutics & Drug Disposition

    2 publications · 30 citations

    2

    h-index

  3. Xenobiotica

    1 publications · 33 citations

    1

    h-index

  4. Clinical Therapeutics

    1 publications · 17 citations

    1

    h-index

  5. European Journal of Clinical Pharmacology

    1 publications · 20 citations

    1

    h-index

1–5