Noncoding DNA Constraint is a genomic conservation measure that quantifies the degree to which noncoding DNA sequences are functionally constrained against nucleotide changes through evolutionary time, distinguishing it from neutral or unconstrained noncoding regions by reflecting selective pressures indicative of regulatory or structural importance.
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2017–2026
1
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26
Conserved noncoding sequences are selectively constrained and not mutation cold spots
Jared A. Drake, Christine Bird, James Nemesh et al. · Nature Genetics · 2005 · 237 citations
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University of Edinburgh
Edinburgh, United Kingdom
5 h-index
13 publications
1.3K citations
Broad Institute
Cambridge, United States
2 h-index
47 publications
15K citations
University of Cambridge
Cambridge, United Kingdom
2 h-index
2 publications
176 citations
Massachusetts General Hospital
Boston, United States
2 h-index
2 publications
562 citations
National Centre of Scientific Research "Demokritos"
Athens, Greece
2 h-index
4 publications
172 citations
Massachusetts Institute of Technology
Cambridge, United States
1 h-index
4 publications
948 citations
University of Bern
Bern, Switzerland
1 h-index
1 publications
237 citations
University of Nebraska–Lincoln
Lincoln, United States
1 h-index
2 publications
22 citations
1–8 of 46
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- Genome Research
GR · 3 publications · 525 citations
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- Molecular Biology and Evolution
MBE · 2 publications · 136 citations
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- Science
2 publications · 26 citations
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- Physica A Statistical Mechanics and its Applications
2 publications · 86 citations
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- Journal of Molecular Evolution
2 publications · 32 citations
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