Concepedia

Nitroreduction Of Carcinogens

Nitroreduction of Carcinogens is a metabolic process in which nitroaromatic carcinogens are enzymatically reduced to yield reactive intermediates capable of forming DNA adducts, thereby initiating mutagenic and carcinogenic events.

60

Publications

2.3K

Citations

184

Authors

73

Institutions

Publications per year

2017–2026

4

Parents

Publications

60

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells

Richard J. Knox, Frank Friedlos, Michael Jarman et al. · Biochemical Pharmacology · 1988 · 166 citations

, , +9

The enzymatic reduction of the N-hydroxy derivatives of 2-acetylaminofluorene and related carcinogens by tissue preparations.

Prabhakar D. Lotlikar, Elizabeth C. Miller, James A. Miller et al. · PubMed · 1965 · 151 citations

, , +6

Characteristics of nitro reduction of the carcinogenic agent, 4-nitroquinolone N-oxide

Ryuji Kato, Atsushi Takahashi, Takehiro Oshima · Biochemical Pharmacology · 1970 · 133 citations

, , +11

Reduction of the carcinogen 1-nitropyrene to 1-aminopyrene by rat intestinal bacteria

Paul C. Howard, Frederick A. Beland, Carl E. Cerniglia · Carcinogenesis · 1983 · 120 citations

, , +13

Activation of nitrofurantoin to a mutagen by rat liver nitroreductase

Herbert S. Rosenkranz, William T. Speck · Biochemical Pharmacology · 1976 · 119 citations

, , +9

1–5 of 60

Authors

184

  1. KE
    Karam El‐Bayoumy

    Institute for Cancer Prevention, United States

    6 publications · 113 citations

    6

    h-index

  2. PP
    Peter P. Fu

    National Center for Toxicological Research, United States

    5 publications · 107 citations

    5

    h-index

  3. FA
    Frederick A. Beland

    National Center for Toxicological Research, United States

    5 publications · 224 citations

    5

    h-index

  4. RH
    Robert H. Heflich

    National Center for Toxicological Research, United States

    4 publications · 99 citations

    4

    h-index

  5. CE
    Carl E. Cerniglia

    National Center for Toxicological Research, United States

    4 publications · 213 citations

    4

    h-index

1–5 of 184

Institutions

73

  1. National Center for Toxicological Research

    Pine Bluff, United States

    12 h-index

    34 publications

    1.2K citations

  2. Institute for Cancer Prevention

    Valhalla, United States

    4 h-index

    17 publications

    282 citations

  3. University of Minnesota Medical Center

    Minneapolis, United States

    3 h-index

    9 publications

    261 citations

  4. Environmental Protection Agency

    Washington, United States

    3 h-index

    12 publications

    304 citations

  5. National Cancer Institute

    Bethesda, United States

    2 h-index

    5 publications

    245 citations

  6. Tokushima University

    Tokushima, Japan

    2 h-index

    7 publications

    129 citations

  7. Case Western Reserve University

    Cleveland, United States

    2 h-index

    4 publications

    154 citations

  8. Translational Therapeutics (United States)

    Arlington, United States

    2 h-index

    7 publications

    131 citations

1–8 of 73

Venues

  1. Carcinogenesis

    15 publications · 609 citations

    14

    h-index

  2. Chemical Research in Toxicology

    8 publications · 157 citations

    8

    h-index

  3. PubMed

    Repository · 7 publications · 395 citations

    7

    h-index

  4. Biochemical Pharmacology

    6 publications · 529 citations

    6

    h-index

  5. Mutation Research Letters

    3 publications · 76 citations

    3

    h-index

1–5