Concepedia

Mutational Stability Effects

Mutational Stability Effects is a thermodynamic construct that quantifies the change in protein folding stability resulting from amino acid substitutions, distinguishing it from other folding determinants by specifically characterizing the energetic impact of mutations on the native versus denatured state equilibrium.

270

Publications

15.3K

Citations

1.1K

Authors

412

Institutions

Publications per year

2017–2026

47

Parents

Publications

270

Additivity of mutational effects in proteins

James Wells · Biochemistry · 1990 · 669 citations

, , +10

How Protein Stability and New Functions Trade Off

Nobuhiko Tokuriki, François Stricher, Luís Serrano et al. · PLoS Computational Biology · 2008 · 610 citations · Full text

, , +17

The Stability Effects of Protein Mutations Appear to be Universally Distributed

Nobuhiko Tokuriki, François Stricher, Joost Schymkowitz et al. · Journal of Molecular Biology · 2007 · 466 citations

, , +8

Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details

Vladimir Potapov, Marion C. Cohen, Gideon Schreiber · Protein Engineering Design and Selection · 2009 · 368 citations · Full text

, , +17

Using AlphaFold to predict the impact of single mutations on protein stability and function

Marina A. Pak, Karina A. Markhieva, Mariia S. Novikova et al. · PLoS ONE · 2023 · 288 citations · Full text

, , +13

1–5 of 270

Authors

1.1K

  1. BE
    Bruce E. Bowler

    University of Denver, United States

    6 publications · 151 citations

    6

    h-index

  2. MM
    M. Michael Gromiha

    Indian Institute of Technology Madras, India

    6 publications · 368 citations

    6

    h-index

  3. GC
    Giorgio Colombo

    Institute of Chemistry of Molecular Recognition, Italy

    4 publications · 165 citations

    4

    h-index

  4. AN
    Athi N. Naganathan

    Indian Institute of Technology Madras, India

    4 publications · 245 citations

    4

    h-index

  5. AS
    Akinori Sarai

    Kyushu Institute of Technology, Japan

    4 publications · 284 citations

    4

    h-index

1–5 of 1.1K

Institutions

412

  1. University of Cambridge

    Cambridge, United Kingdom

    10 h-index

    34 publications

    2.1K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    24 publications

    1K citations

  3. Universidad de Granada

    Granada, Spain

    6 h-index

    24 publications

    872 citations

  4. California Institute of Technology

    Pasadena, United States

    6 h-index

    18 publications

    1.7K citations

  5. University of Toronto

    Toronto, Canada

    6 h-index

    22 publications

    1K citations

  6. University of Oregon

    Eugene, United States

    5 h-index

    14 publications

    658 citations

  7. University of Washington

    Seattle, United States

    5 h-index

    9 publications

    250 citations

  8. Institute of Chemistry of Molecular Recognition

    Milan, Italy

    5 h-index

    15 publications

    658 citations

1–8 of 412

Venues

  1. Biochemistry

    44 publications · 2.9K citations

    30

    h-index

  2. Protein Science

    PS · 23 publications · 870 citations

    16

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 1.8K citations

    15

    h-index

  4. Protein Engineering Design and Selection

    PEDS · 14 publications · 861 citations

    13

    h-index

  5. Journal of Biological Chemistry

    JBC · 13 publications · 646 citations

    12

    h-index

1–5