Concepedia

Mutational Landscapes

Mutational Landscapes is a computational framework that characterizes the spatial and functional distribution of genetic variants within a population or genome, distinguished by its integration of mutation frequency, selective pressures, and genomic context to model the heterogeneity of mutational effects.

445

Publications

37.9K

Citations

4.3K

Authors

1.2K

Institutions

Publications per year

2017–2026

195

Variants

Mutation Landscapes

Parents

Publications

445

deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Rachel Rosenthal, Nicholas McGranahan, Javier Herrero et al. · Genome biology · 2016 · 1.3K citations · Full text

, , +17

A genomic mutational constraint map using variation in 76,156 human genomes

Siwei Chen, Laurent C. Francioli, Julia K. Goodrich et al. · Nature · 2023 · 1.3K citations · Full text

, , +14

Pan-cancer whole-genome analyses of metastatic solid tumours

Peter Priestley, Jonathan Baber, Martijn P. Lolkema et al. · Nature · 2019 · 1.2K citations · Full text

, , +17

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

Valsamo Anagnostou, Kellie N. Smith, Patrick M. Forde et al. · Cancer Discovery · 2016 · 899 citations · Full text

, , +17

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

Matthew T. Chang, Saurabh Asthana, Sizhi Paul Gao et al. · Nature Biotechnology · 2015 · 832 citations

, , +16

1–5 of 445

Authors

4.3K

  1. IM
    Iñigo Martincorena

    Wellcome Sanger Institute, United Kingdom

    12 publications · 2.4K citations

    12

    h-index

  2. PJ
    Peter J. Campbell

    Wellcome Sanger Institute, United Kingdom

    12 publications · 2.3K citations

    12

    h-index

  3. AH
    Annette Hervey

    New York Botanical Garden, United States

    9 publications · 750 citations

    9

    h-index

  4. WJ
    William J. Rôbbins

    New York Botanical Garden, United States

    9 publications · 750 citations

    9

    h-index

  5. MR
    Michael R. Stratton

    Wellcome Sanger Institute, United Kingdom

    7 publications · 1.8K citations

    7

    h-index

1–5 of 4.3K

Institutions

1.2K

  1. Harvard University

    Cambridge, United States

    25 h-index

    115 publications

    37.8K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    21 h-index

    60 publications

    5.3K citations

  3. University of Cambridge

    Cambridge, United Kingdom

    20 h-index

    88 publications

    15.9K citations

  4. Wellcome Sanger Institute

    Cambridge, United Kingdom

    17 h-index

    190 publications

    43K citations

  5. Memorial Sloan Kettering Cancer Center

    New York, United States

    15 h-index

    131 publications

    21.5K citations

  6. Massachusetts General Hospital

    Boston, United States

    13 h-index

    117 publications

    67.2K citations

  7. Cornell University

    Ithaca, United States

    13 h-index

    46 publications

    5.5K citations

  8. Broad Institute

    Cambridge, United States

    13 h-index

    278 publications

    164.2K citations

1–8 of 1.2K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 55 publications · 3.7K citations

    30

    h-index

  2. Evolution

    17 publications · 2.5K citations

    17

    h-index

  3. Nature Communications

    16 publications · 1.6K citations

    15

    h-index

  4. PLoS Computational Biology

    12 publications · 622 citations

    12

    h-index

  5. Scientific Reports

    11 publications · 467 citations

    11

    h-index

1–5