Pan-cancer whole-genome analyses of metastatic solid tumours

Peter Priestley, Jonathan Baber, Martijn P. Lolkema, +18

Nature

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

Marie Wong, Chelsea Mayoh, Loretta M. S. Lau, +45

Nature Medicine

Functional GenomicsHigh-risk Pediatric CancerMedicineEpigenetic ChangeEpigenomics +7

Pan-cancer whole-genome comparison of primary and metastatic solid tumours

Francisco Martínez-Jiménez, Ali Movasati, Sascha R. Brunner, +4

Nature

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

Sharon Christensen, Bastiaan van der Roest, Nicolle Besselink, +8

Nature Communications

GRIDSS2: comprehensive characterisation of somatic structural variation using single breakend variants and structural variant phasing

Daniel Cameron, Jonathan Baber, Charles Shale, +7

Genome biology

Genetic immune escape landscape in primary and metastatic cancer

Francisco Martínez-Jiménez, Peter Priestley, Charles Shale, +3

Nature Genetics

Immune Escape PathwaysMetastatic CancerCancer ImmunosurveillanceTumor HeterogeneityMedicine +12

Unscrambling cancer genomes via integrated analysis of structural variation and copy number

Charles Shale, Daniel Cameron, Jonathan Baber, +5

Cell Genomics

GRIDSS, PURPLE, LINX: Unscrambling the tumor genome via integrated analysis of structural variation and copy number

Daniel Cameron, Jonathan Baber, Charles Shale, +5

Structural VariationEngineeringGeneticsGenomicsCopy Number +17

A multi-platform reference for somatic structural variation detection

Jose Espejo Valle-Inclán, Nicolle Besselink, Ewart de Bruijn, +15

Cell Genomics

Heritable defects in telomere and mitotic function selectively predispose to sarcomas

Mandy L. Ballinger, Swetansu Pattnaik, Piyushkumar A. Mundra, +52

Science

Cancer SusceptibilityGenome InstabilityCell DivisionTumor HeterogeneityExtreme Phenotype Design +12