Concepedia

Mutation Rate Optimization

Mutation Rate Optimization is a methodological framework in error-prone mutagenesis that systematically adjusts the frequency and distribution of induced mutations to maximize the yield of beneficial genetic variants while minimizing deleterious or lethal mutations.

24

Publications

1.8K

Citations

84

Authors

41

Institutions

Publications per year

2017–2026

7

Parents

Publications

24

Optimal Mutation Rates in Genetic Search

Thomas Bäck · 1993 · 372 citations

, , +11

Scalable, Continuous Evolution of Genes at Mutation Rates above Genomic Error Thresholds

Arjun Ravikumar, Garri A. Arzumanyan, Muaeen K.A. Obadi et al. · Cell · 2018 · 315 citations · Full text

, , +16

Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing

Justin Jee, Aviram Rasouly, Ilya Shamovsky et al. · Nature · 2016 · 168 citations · Full text

, , +12

Optimum mutation rate and degree of dominance as determined by the principle of minimum genetic load

Journal of Genetics · 1960 · 105 citations

, , +14

A Model for Designing Adaptive Laboratory Evolution Experiments

Ryan A. LaCroix, Bernhard Ø. Palsson, Adam M. Feist · Applied and Environmental Microbiology · 2017 · 104 citations · Full text

, , +14

1–5 of 24

Authors

84

  1. DM
    Dusan Misevic

    Université Paris Cité, France

    2 publications · 187 citations

    2

    h-index

  2. SF
    Santiago F. Elena

    Instituto de Biología Molecular y Celular de Plantas, Spain

    2 publications · 187 citations

    2

    h-index

  3. RE
    Richard E. Lenski

    Michigan State University, United States

    2 publications · 187 citations

    2

    h-index

  4. CO
    Charles Ofria

    Michigan State University, United States

    2 publications · 187 citations

    2

    h-index

  5. JC
    Jeff Clune

    University of Wyoming, United States

    2 publications · 187 citations

    2

    h-index

1–5 of 84

Institutions

41

  1. ETH Zurich

    Zurich, Switzerland

    3 h-index

    9 publications

    285 citations

  2. Universitat Politècnica de València

    Valencia, Spain

    2 h-index

    6 publications

    561 citations

  3. Santa Fe Institute

    Santa Fe, United States

    2 h-index

    2 publications

    131 citations

  4. Michigan State University

    East Lansing, United States

    2 h-index

    5 publications

    470 citations

  5. Technical University of Denmark

    Kongens Lyngby, Denmark

    2 h-index

    4 publications

    316 citations

  6. Consejo Superior de Investigaciones Científicas

    Madrid, Spain

    1 h-index

    3 publications

    288 citations

  7. Kyoto University

    Kyoto, Japan

    1 h-index

    2 publications

    26 citations

  8. Chalmers University of Technology

    Gothenburg, Sweden

    1 h-index

    1 publications

    35 citations

1–8 of 41

Venues

  1. Computational Statistics

    1 publications · 15 citations

    1

    h-index

  2. Applied and Environmental Microbiology

    AEM · 1 publications · 104 citations

    1

    h-index

  3. Nature

    1 publications · 168 citations

    1

    h-index

  4. PLoS Computational Biology

    1 publications · 96 citations

    1

    h-index

  5. Proceedings of the Genetic and Evolutionary Computation Conference

    Conference · 1 publications · 54 citations

    1

    h-index

1–5