Concepedia

Mutation Effects On Channel Function

Mutation Effects On Channel Function is a scientific construct in chloride channel biophysics that characterizes the functional alterations in ion channel behavior, kinetics, or regulation resulting from specific genetic mutations, thereby distinguishing how such variations disrupt normal chloride conductance, gating, or cellular localization compared to wild-type channels.

193

Publications

16.8K

Citations

908

Authors

305

Institutions

Publications per year

2017–2026

21

Parents

Publications

193

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Stefan Feske, Yousang Gwack, Murali Prakriya et al. · Nature · 2006 · 2.3K citations

, , +10

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

Matthew P. Anderson, Richard J. Gregory, Simon Thompson et al. · Science · 1991 · 1.1K citations

, , +17

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

Andriy V. Yeromin, Shenyuan L. Zhang, Weihua Jiang et al. · Nature · 2006 · 804 citations · Full text

, , +16

Calcium channel characteristics conferred on the sodium channel by single mutations

Stefan H. Heinemann, Heinrich Terlau, Walter Stühmer et al. · Nature · 1992 · 787 citations

, , +16

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

Diane M. Papazian, Leslie C. Timpe, Yuh Nung Jan et al. · Nature · 1991 · 509 citations

, , +13

1–5 of 193

Authors

908

  1. MJ
    Michael J. Welsh

    Howard Hughes Medical Institute, United States

    8 publications · 1.8K citations

    8

    h-index

  2. PL
    Paul Linsdell

    Dalhousie University, Canada

    6 publications · 297 citations

    6

    h-index

  3. DN
    David N. Sheppard

    University of Bristol, United Kingdom

    5 publications · 227 citations

    5

    h-index

  4. TJ
    Thomas J. Jentsch

    Universität Hamburg, Germany

    4 publications · 619 citations

    4

    h-index

  5. ZC
    Zhiwei Cai

    University of Bristol, United Kingdom

    4 publications · 165 citations

    4

    h-index

1–5 of 908

Institutions

305

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    15 h-index

    40 publications

    8.7K citations

  2. University of Iowa

    Iowa City, United States

    8 h-index

    18 publications

    3.8K citations

  3. University College London

    London, United Kingdom

    7 h-index

    20 publications

    553 citations

  4. Harvard University

    Cambridge, United States

    6 h-index

    15 publications

    9.1K citations

  5. University of Bristol

    Bristol, United Kingdom

    6 h-index

    28 publications

    787 citations

  6. Universität Hamburg

    Hamburg, Germany

    6 h-index

    23 publications

    2.8K citations

  7. University of Oxford

    Oxford, United Kingdom

    5 h-index

    11 publications

    241 citations

  8. Istituto Giannina Gaslini

    Genoa, Italy

    5 h-index

    24 publications

    945 citations

1–8 of 305

Venues

  1. Journal of Biological Chemistry

    JBC · 19 publications · 1.4K citations

    18

    h-index

  2. The Journal of General Physiology

    JGP · 18 publications · 1.1K citations

    15

    h-index

  3. The Journal of Physiology

    15 publications · 747 citations

    15

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 740 citations

    10

    h-index

  5. FEBS Letters

    8 publications · 806 citations

    8

    h-index

1–5