Concepedia

Multivalent Ligand Targeting

Multivalent Ligand Targeting is a ligand-mediated targeting strategy that employs multiple binding moieties on a single molecular scaffold to enhance binding affinity and specificity through simultaneous interactions with spatially clustered receptors on target cells.

34

Publications

1.1K

Citations

239

Authors

86

Institutions

Publications per year

2017–2026

17

Parents

Publications

34

Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer–doxorubicin conjugates to human colon cancer cells

Ayelet David, Pavla Kopečková, Tamara Minko et al. · European Journal of Cancer · 2003 · 109 citations

, , +17

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Stefania Ordanini, Norbert Varga, Vanessa Porkolab et al. · Chemical Communications · 2015 · 92 citations · Full text

, , +16

Heterobivalent ligands target cell-surface receptor combinations in vivo

Liping Xu, J.S. Josan, Josef Vágner et al. · Proceedings of the National Academy of Sciences · 2012 · 72 citations · Full text

, , +17

Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of α-MSH

Josef Vágner, Heather L. Handl, Robert J. Gillies et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 66 citations · Full text

, , +16

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

Anneleen Van Hout, Vladimir Bobkov, Jordi Doijen et al. · Biochemical Pharmacology · 2018 · 59 citations · Full text

, , +16

1–5 of 34

Authors

239

  1. NN
    Nima Nassehi

    Virginia Commonwealth University, United States

    2 publications · 23 citations

    2

    h-index

  2. DE
    Dana E. Selley

    Virginia Commonwealth University, United States

    2 publications · 23 citations

    2

    h-index

  3. ML
    Mengchu Li

    Technical University of Munich, Germany

    2 publications · 23 citations

    2

    h-index

  4. JV
    Josef Vágner

    University of Arizona, United States

    2 publications · 138 citations

    2

    h-index

  5. VB
    Victor Barreto‐de‐Souza

    Universidade Federal do Rio de Janeiro, Brazil

    2 publications · 23 citations

    2

    h-index

1–5 of 239

Institutions

86

  1. Virginia Commonwealth University

    Richmond, United States

    2 h-index

    23 publications

    263 citations

  2. University of California San Diego

    San Diego, United States

    2 h-index

    5 publications

    197 citations

  3. University of Milan

    Milan, Italy

    2 h-index

    8 publications

    594 citations

  4. University of Arizona

    Tucson, United States

    2 h-index

    9 publications

    624 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    10 publications

    493 citations

  6. Maharaja Sayajirao University of Baroda

    Vadodara, India

    1 h-index

    5 publications

    60 citations

  7. University of Illinois Urbana-Champaign

    Urbana, United States

    1 h-index

    8 publications

    384 citations

  8. Nubad (United States)

    Greenville, United States

    1 h-index

    2 publications

    76 citations

1–8 of 86

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    5 publications · 123 citations

    5

    h-index

  2. Bioorganic & Medicinal Chemistry

    2 publications · 51 citations

    2

    h-index

  3. Bioconjugate Chemistry

    2 publications · 38 citations

    2

    h-index

  4. Chemical Communications

    ChemComm · 2 publications · 111 citations

    2

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 120 citations

    2

    h-index

1–5