Lanthanide-based time-resolved fluorescence of in cyto ligand–receptor interactions

Heather L. Handl, Josef Vágner, Henry I. Yamamura, +2

Analytical Biochemistry

EngineeringBiochemistrySingle-molecule DetectionBioimagingLanthanide-based Time-resolved Fluorescence +2

Heterobivalent Ligands Crosslink Multiple Cell‐Surface Receptors: The Human Melanocortin‐4 and δ‐Opioid Receptors

Josef Vágner, Liping Xu, Heather L. Handl, +5

Angewandte Chemie International Edition

Drug TargetSynthetic HeterobivalentPeptide SciencePharmacotherapyMolecular Pharmacology +21

Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of α-MSH

Josef Vágner, Heather L. Handl, Robert J. Gillies, +1

Bioorganic & Medicinal Chemistry Letters

Drug TargetingBiochemistryMultimeric LigandsMedicineDrug Delivery Systems +3

Synthesis and Evaluation of Bivalent NDP-α-MSH(7) Peptide Ligands for Binding to the Human Melanocortin Receptor 4 (hMC4R)

Heather L. Handl, Rajesh Sankaranarayanan, J.S. Josan, +4

Bioconjugate Chemistry

Cell-Specific Targeting by Heterobivalent Ligands

J.S. Josan, Heather L. Handl, Rajesh Sankaranarayanan, +6

Bioconjugate Chemistry

Peptide ScienceImmunotherapeuticsTumor BiologyHeterobivalent LigandsMolecular Pharmacology +14

Development of a lanthanide-based assay for detection of receptor–ligand interactions at the δ-opioid receptor

Heather L. Handl, Josef Vágner, Henry I. Yamamura, +2

Analytical Biochemistry

Molecular Pharmacologyδ-Opioid ReceptorBiochemistryMedicineLanthanide-based Assay +5

Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-Cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-Cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues

Tiffany T. Howard, Brian M. Lingerfelt, Bethany L. Purnell, +11

Bioorganic & Medicinal Chemistry

Bioorganic ChemistryBiochemistryMedicineNatural SciencesNovel Furano Analogues +7

Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors

J.S. Josan, Josef Vágner, Heather L. Handl, +3

International Journal of Peptide Research and Therapeutics

Combinatorial ChemistrySolid-phase SynthesisBiochemistryFunctional SelectivityHeterobivalent Ligands Targeted +6

A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties

Stanley Kupchinsky, Sara Centioni, Tiffany T. Howard, +14

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryPharmaceutical ScienceBioorganic ChemistryDna Binding +11

Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA

Kristen Daniell, Michelle Stewart, Erik Madsen, +6

Bioorganic & Medicinal Chemistry Letters

MedicineAchiral AnalogsBiological EvaluationAntimicrobial ChemotherapyAntimicrobial Compound +5