Concepedia

Multivalent Inhibitors

Multivalent Inhibitors is a class of synthetic or natural ligands that contain multiple binding sites capable of simultaneously engaging with multiple receptors or epitopes on a target molecule or cell surface, thereby enhancing binding affinity and selectivity through cooperative multivalent interactions.

126

Publications

8.6K

Citations

742

Authors

254

Institutions

Publications per year

2017–2026

40

Parents

Publications

126

Multivalency as a Chemical Organization and Action Principle

Carlo Fasting, Christoph A. Schalley, Marcus Weber et al. · Angewandte Chemie International Edition · 2012 · 992 citations

, , +16

Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture

Jason E. Gestwicki, Christopher W. Cairo, Laura E. Strong et al. · Journal of the American Chemical Society · 2002 · 699 citations

, , +16

Multivalent Effects of RGD Peptides Obtained by Nanoparticle Display

Xavier Montet, Martin Funovics, Karin Montet-Abou et al. · Journal of Medicinal Chemistry · 2006 · 384 citations

, , +17

In Situ Selection of Lead Compounds by Click Chemistry:  Target-Guided Optimization of Acetylcholinesterase Inhibitors

Antoni Krasiński, Zoran Radić, Roman Manetsch et al. · Journal of the American Chemical Society · 2005 · 339 citations

, , +17

Multivalent Small-Molecule Pan-RAS Inhibitors

Matthew Welsch, Anna Kaplan, Jennifer M. Chambers et al. · Cell · 2017 · 283 citations · Full text

, , +12

1–5 of 126

Authors

742

  1. RH
    Rainer Haag

    Freie Universität Berlin, Germany

    8 publications · 1.6K citations

    8

    h-index

  2. CO
    Carmen Ortiz Mellet

    Universidad de Sevilla, Spain

    7 publications · 466 citations

    7

    h-index

  3. PC
    Philippe Compain

    Centre National de la Recherche Scientifique, France

    7 publications · 371 citations

    7

    h-index

  4. RJ
    Roland J. Pieters

    Utrecht University, Netherlands

    6 publications · 256 citations

    6

    h-index

  5. PI
    Pavel I. Kitov

    University of Alberta, Canada

    6 publications · 416 citations

    6

    h-index

1–5 of 742

Institutions

254

  1. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    99 publications

    4.6K citations

  2. Universidad de Sevilla

    Seville, Spain

    11 h-index

    25 publications

    1.5K citations

  3. Université de Strasbourg

    Strasbourg, France

    11 h-index

    45 publications

    2.5K citations

  4. Freie Universität Berlin

    Berlin, Germany

    9 h-index

    35 publications

    7.9K citations

  5. Laboratoire de Synthèse Organique

    Palaiseau, France

    6 h-index

    26 publications

    1.4K citations

  6. Biotechnology Institute

    Washington D.C., United States

    6 h-index

    16 publications

    635 citations

  7. University of Alberta

    Edmonton, Canada

    6 h-index

    27 publications

    1.9K citations

  8. Utrecht University

    Utrecht, The Netherlands

    6 h-index

    31 publications

    1.3K citations

1–8 of 254

Venues

  1. Chemistry - A European Journal

    14 publications · 719 citations

    14

    h-index

  2. Journal of the American Chemical Society

    JACS · 11 publications · 1.7K citations

    11

    h-index

  3. Journal of Medicinal Chemistry

    8 publications · 564 citations

    8

    h-index

  4. Angewandte Chemie International Edition

    8 publications · 1.7K citations

    8

    h-index

  5. ChemBioChem

    6 publications · 311 citations

    6

    h-index

1–5