Concepedia

Multivalent Interactions

Multivalent Interactions is a molecular recognition phenomenon in which a single macromolecular entity simultaneously engages multiple binding sites on a target through concerted, spatially organized affinity interactions, thereby enhancing binding avidity and specificity beyond monovalent interactions.

774

Publications

51K

Citations

3.5K

Authors

920

Institutions

Publications per year

2017–2026

223

Variants

Multivalency

Parents

Children

Publications

774

Phase transitions in the assembly of multivalent signalling proteins

Pilong Li, Sudeep Banjade, Hui-Chun Cheng et al. · Nature · 2012 · 2.7K citations

, , +14

Multivalency as a Chemical Organization and Action Principle

Carlo Fasting, Christoph A. Schalley, Marcus Weber et al. · Angewandte Chemie International Edition · 2012 · 992 citations

, , +16

Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis

Chang-Deng Hu, Tom K. Kerppola · Nature Biotechnology · 2003 · 783 citations · Full text

, , +13

Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture

Jason E. Gestwicki, Christopher W. Cairo, Laura E. Strong et al. · Journal of the American Chemical Society · 2002 · 699 citations

, , +16

The Interaction Properties of Costimulatory Molecules Revisited

Alison V. Collins, Douglas W. Brodie, Robert J.C. Gilbert et al. · Immunity · 2002 · 680 citations · Full text

, , +12

1–5 of 774

Authors

3.5K

  1. JH
    Jurriaan Huskens

    University of Twente, Netherlands

    13 publications · 804 citations

    12

    h-index

  2. DN
    David N. Reinhoudt

    University of Twente, Netherlands

    10 publications · 639 citations

    10

    h-index

  3. RH
    Rainer Haag

    Freie Universität Berlin, Germany

    9 publications · 1.3K citations

    9

    h-index

  4. DK
    David K. Smith

    University of York, United Kingdom

    9 publications · 412 citations

    9

    h-index

  5. DF
    Daan Frenkel

    Institute for Atomic and Molecular Physics, Netherlands

    7 publications · 503 citations

    7

    h-index

1–5 of 3.5K

Institutions

920

  1. Centre National de la Recherche Scientifique

    Paris, France

    27 h-index

    168 publications

    8.1K citations

  2. Freie Universität Berlin

    Berlin, Germany

    21 h-index

    87 publications

    9.5K citations

  3. National Institutes of Health

    Bethesda, United States

    18 h-index

    86 publications

    6.5K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    18 h-index

    66 publications

    33.4K citations

  5. University of Cambridge

    Cambridge, United Kingdom

    16 h-index

    56 publications

    2.5K citations

  6. University of Twente

    Enschede, The Netherlands

    15 h-index

    74 publications

    5.2K citations

  7. Harvard University

    Cambridge, United States

    15 h-index

    45 publications

    5.3K citations

  8. University of Leeds

    Leeds, United Kingdom

    15 h-index

    69 publications

    6.9K citations

1–8 of 920

Venues

  1. Journal of the American Chemical Society

    JACS · 72 publications · 7.2K citations

    47

    h-index

  2. Angewandte Chemie International Edition

    26 publications · 2.5K citations

    23

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 24 publications · 2.1K citations

    22

    h-index

  4. Biophysical Journal

    20 publications · 880 citations

    18

    h-index

  5. Chemistry - A European Journal

    23 publications · 868 citations

    18

    h-index

1–5