Concepedia

Multi-region Sequencing

Multi-Region Sequencing is a genomic profiling method that involves the spatially stratified sampling and high-throughput sequencing of multiple distinct regions within a single tumor or across multiple tumors in the same patient to capture intratumoral and intertumoral heterogeneity, thereby enabling the reconstruction of clonal evolution trajectories.

68

Publications

15.8K

Citations

1.3K

Authors

339

Institutions

Publications per year

2017–2026

53

Parents

Publications

68

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Marco Gerlinger, Andrew J. Rowan, Stuart Horswell et al. · New England Journal of Medicine · 2012 · 7.8K citations · Full text

, , +14

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

Marco Gerlinger, Stuart Horswell, James Larkin et al. · Nature Genetics · 2014 · 1.3K citations · Full text

, , +13

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

Jianjun Zhang, Junya Fujimoto, Jianhua Zhang et al. · Science · 2014 · 1K citations

, , +17

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

Lucy Yates, Moritz Gerstung, Stian Knappskog et al. · Nature Medicine · 2015 · 840 citations · Full text

, , +16

Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

KC Allen Chan, Peiyong Jiang, Yama W. L. Zheng et al. · Clinical Chemistry · 2012 · 489 citations · Full text

, , +17

1–5 of 68

Authors

1.3K

  1. CS
    Charles Swanton

    University College London, United Kingdom

    6 publications · 9.4K citations

    6

    h-index

  2. MG
    Marco Gerlinger

    Institute of Cancer Research, United Kingdom

    4 publications · 9.1K citations

    4

    h-index

  3. GC
    Giulio Caravagna

    Institute of Cancer Research, United Kingdom

    4 publications · 326 citations

    4

    h-index

  4. NM
    Nicholas McGranahan

    University College London, United Kingdom

    4 publications · 1.5K citations

    4

    h-index

  5. AS
    Andrea Sottoriva

    Institute of Cancer Research, United Kingdom

    4 publications · 321 citations

    4

    h-index

1–5 of 1.3K

Institutions

339

  1. Institute of Cancer Research

    London, United Kingdom

    8 h-index

    41 publications

    2K citations

  2. The University of Texas MD Anderson Cancer Center

    Houston, United States

    8 h-index

    102 publications

    37.2K citations

  3. Peking University

    Beijing, China

    7 h-index

    46 publications

    4.2K citations

  4. University College London

    London, United Kingdom

    6 h-index

    171 publications

    239.4K citations

  5. Peking University Cancer Hospital

    Beijing, China

    5 h-index

    16 publications

    818 citations

  6. Harvard University

    Cambridge, United States

    5 h-index

    13 publications

    8.4K citations

  7. The University of Tokyo

    Tokyo, Japan

    5 h-index

    14 publications

    1.2K citations

  8. London Cancer

    London, United Kingdom

    4 h-index

    89 publications

    11.4K citations

1–8 of 339

Venues

  1. Nature Communications

    16 publications · 1.8K citations

    16

    h-index

  2. Genome Medicine

    3 publications · 207 citations

    3

    h-index

  3. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 3 publications · 41 citations

    3

    h-index

  4. New England Journal of Medicine

    NEJM · 2 publications · 7.9K citations

    2

    h-index

  5. Scientific Reports

    2 publications · 72 citations

    2

    h-index

1–5