Concepedia

Multi-enzyme Cascade Design

Multi-Enzyme Cascade Design is a synthetic biochemical framework that orchestrates the sequential and often spatially organized action of multiple enzymes within a single pathway to enhance catalytic efficiency, substrate channeling, and metabolic flux while minimizing side reactions and intermediate diffusion.

44

Publications

2.5K

Citations

270

Authors

85

Institutions

Publications per year

2017–2026

34

Parents

Publications

44

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

Mark A. Huffman, Anna Fryszkowska, Oscar Alvizo et al. · Science · 2019 · 631 citations

, , +17

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

Scott P. France, Lorna J. Hepworth, Nicholas J. Turner et al. · ACS Catalysis · 2016 · 424 citations · Full text

, , +17

Functional Cellular Mimics for the Spatiotemporal Control of Multiple Enzymatic Cascade Reactions

Xiaoling Liu, Petr Formánek, Brigitte Voit et al. · Angewandte Chemie International Edition · 2017 · 94 citations

, , +15

Getting the Most Out of Enzyme Cascades: Strategies to Optimize In Vitro Multi-Enzymatic Reactions

Regine Siedentop, Christiane Claaßen, Dörte Rother et al. · Catalysts · 2021 · 86 citations · Full text

, , +14

Multi-enzyme logic network architectures for assessing injuries: digital processing of biomarkers

Jan Halámek, Vera Bocharova, Soujanya Chinnapareddy et al. · Molecular BioSystems · 2010 · 83 citations

, , +17

1–5 of 44

Authors

270

  1. SL
    Sabine L. Flitsch

    University of Manchester, United Kingdom

    2 publications · 446 citations

    2

    h-index

  2. BV
    Brigitte Voit

    Leibniz Institute of Polymer Research, Germany

    2 publications · 124 citations

    2

    h-index

  3. PF
    Petr Formánek

    Leibniz Institute of Polymer Research, Germany

    2 publications · 124 citations

    2

    h-index

  4. EK
    Evgeny Katz

    Clarkson University, United States

    2 publications · 115 citations

    2

    h-index

  5. SS
    Sharad Sarak

    Konkuk University, South Korea

    2 publications · 34 citations

    2

    h-index

1–5 of 270

Institutions

85

  1. State Key Laboratory of Food Science and Technology

    Wuxi, China

    4 h-index

    18 publications

    353 citations

  2. Jiangnan University

    Wuxi, China

    3 h-index

    18 publications

    372 citations

  3. Seoul National University

    Seoul, South Korea

    2 h-index

    4 publications

    60 citations

  4. Technische Universität Dresden

    Dresden, Germany

    2 h-index

    4 publications

    248 citations

  5. University of Manchester

    Manchester, United Kingdom

    2 h-index

    14 publications

    1.9K citations

  6. Konkuk University

    Seoul, South Korea

    2 h-index

    8 publications

    144 citations

  7. Leibniz Institute of Polymer Research

    Dresden, Germany

    2 h-index

    8 publications

    496 citations

  8. Qilu University of Technology

    Jinan, China

    2 h-index

    7 publications

    299 citations

1–8 of 85

Venues

  1. Chemical Communications

    ChemComm · 3 publications · 67 citations

    3

    h-index

  2. Enzyme and Microbial Technology

    2 publications · 46 citations

    2

    h-index

  3. Chemical Engineering Journal

    2 publications · 105 citations

    2

    h-index

  4. Journal of Biotechnology

    2 publications · 26 citations

    2

    h-index

  5. Biosensors and Bioelectronics

    2 publications · 111 citations

    2

    h-index

1–5