Concepedia

Mrn Complex Function

MRN Complex Function is a molecular mechanism within the DNA damage response machinery that initiates DNA end resection by recognizing and binding to double-strand breaks, thereby facilitating the recruitment and activation of nuclease and helicase activities essential for homologous recombination repair.

188

Publications

17.9K

Citations

1.1K

Authors

405

Institutions

Publications per year

2017–2026

53

Parents

Publications

188

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Ji‐Hoon Lee, Tanya T. Paull · Science · 2005 · 1.4K citations

, , +17

ATM Activation by Oxidative Stress

Zhi Guo, Sergei Kozlov, Martin F. Lavin et al. · Science · 2010 · 1.1K citations · Full text

, , +17

Requirement of the MRN complex for ATM activation by DNA damage

Tamar Uziel, Yaniv Lerenthal, Lilach Moyal et al. · The EMBO Journal · 2003 · 1.1K citations · Full text

, , +14

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Ji‐Hoon Lee, Tanya T. Paull · Science · 2004 · 749 citations

, , +17

BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair

Amitabh V. Nimonkar, Jochen Genschel, Eri Kinoshita et al. · Genes & Development · 2011 · 736 citations · Full text

, , +16

1–5 of 188

Authors

1.1K

  1. TT
    Tanya T. Paull

    The University of Texas at Austin, United States

    12 publications · 4.2K citations

    12

    h-index

  2. JL
    Ji‐Hoon Lee

    The University of Texas at Austin, United States

    7 publications · 2.6K citations

    7

    h-index

  3. DL
    Daqing Li

    University of Maryland, Baltimore, United States

    6 publications · 186 citations

    6

    h-index

  4. BW
    Bert W. O’Malley

    Baylor College of Medicine, United States

    6 publications · 182 citations

    6

    h-index

  5. PR
    Paul Russell

    Scripps Research Institute, United States

    4 publications · 706 citations

    4

    h-index

1–5 of 1.1K

Institutions

405

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    42 publications

    6.8K citations

  2. The University of Texas at Austin

    Austin, United States

    13 h-index

    34 publications

    8.3K citations

  3. University of Pennsylvania

    Philadelphia, United States

    10 h-index

    55 publications

    3.2K citations

  4. Scripps Research Institute

    San Diego, United States

    9 h-index

    33 publications

    4.5K citations

  5. University of Oxford

    Oxford, United Kingdom

    6 h-index

    27 publications

    1.2K citations

  6. National Institutes of Health

    Bethesda, United States

    6 h-index

    17 publications

    1.2K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    42 publications

    2.3K citations

  8. University of Sussex

    Brighton, United Kingdom

    6 h-index

    24 publications

    1.4K citations

1–8 of 405

Venues

  1. Nucleic Acids Research

    16 publications · 985 citations

    15

    h-index

  2. Journal of Virology

    JVI · 12 publications · 832 citations

    12

    h-index

  3. Journal of Biological Chemistry

    JBC · 12 publications · 1.3K citations

    12

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 639 citations

    11

    h-index

  5. Cell Reports

    10 publications · 709 citations

    10

    h-index

1–5