Concepedia

Mre11 Nuclease Function

MRE11 Nuclease Function is a DNA repair enzyme activity characterized by its role in initiating DNA end resection through endonuclease and 3'→5' exonuclease activities, specifically targeting double-strand breaks to generate single-stranded DNA overhangs essential for homologous recombination.

163

Publications

16.7K

Citations

836

Authors

291

Institutions

Publications per year

2017–2026

57

Parents

Publications

163

The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

Tanya T. Paull, Martin Gellert · Molecular Cell · 1998 · 912 citations · Full text

, , +15

BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair

Amitabh V. Nimonkar, Jochen Genschel, Eri Kinoshita et al. · Genes & Development · 2011 · 736 citations · Full text

, , +16

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

Atsushi Shibata, Davide Moiani, A.S. Arvai et al. · Molecular Cell · 2013 · 567 citations · Full text

, , +10

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

Yoshitami Hashimoto, Arnab Ray Chaudhuri, Massimo Lopes et al. · Nature Structural & Molecular Biology · 2010 · 548 citations

, , +11

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

Tanya T. Paull, Martin Gellert · Genes & Development · 1999 · 537 citations · Full text

, , +11

1–5 of 163

Authors

836

  1. TT
    Tanya T. Paull

    The University of Texas at Austin, United States

    12 publications · 2.6K citations

    12

    h-index

  2. LS
    Lorraine S. Symington

    Columbia University Irving Medical Center, United States

    9 publications · 1.1K citations

    10

    h-index

  3. PĆ
    Petr Ćejka

    Università della Svizzera italiana, Switzerland

    9 publications · 1.3K citations

    10

    h-index

  4. JA
    John A. Tainer

    Scripps Research Institute, United States

    10 publications · 2.1K citations

    10

    h-index

  5. EC
    Elda Cannavò

    University of Zurich, Switzerland

    5 publications · 1.1K citations

    7

    h-index

1–5 of 836

Institutions

291

  1. Università della Svizzera italiana

    Lugano, Switzerland

    10 h-index

    20 publications

    1.3K citations

  2. Kyoto University

    Kyoto, Japan

    10 h-index

    35 publications

    1.4K citations

  3. Memorial Sloan Kettering Cancer Center

    New York, United States

    9 h-index

    32 publications

    1.8K citations

  4. Scripps Research Institute

    San Diego, United States

    9 h-index

    53 publications

    13.3K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    25 publications

    2.7K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    22 publications

    1.3K citations

  7. Lawrence Berkeley National Laboratory

    Berkeley, United States

    8 h-index

    16 publications

    4.3K citations

  8. National Institutes of Health

    Bethesda, United States

    8 h-index

    16 publications

    3.3K citations

1–8 of 291

Venues

  1. Nucleic Acids Research

    22 publications · 904 citations

    19

    h-index

  2. Molecular and Cellular Biology

    MCB · 12 publications · 1.4K citations

    12

    h-index

  3. Cell Reports

    10 publications · 528 citations

    10

    h-index

  4. Nature Communications

    9 publications · 621 citations

    10

    h-index

  5. Molecular Cell

    8 publications · 2.1K citations

    8

    h-index

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