Concepedia

Mouse Knockout Lethal Phenotypes

Mouse Knockout Lethal Phenotypes is a genetic construct that refers to the observable developmental or physiological abnormalities in mice resulting in prenatal or postnatal death following the targeted disruption of a specific gene, thereby revealing the gene’s essential function in viability.

310

Publications

46.6K

Citations

2.1K

Authors

579

Institutions

Publications per year

2017–2026

36

Parents

Publications

310

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

Amer A. Beg, William C. Sha, Roderick T. Bronson et al. · Nature · 1995 · 1.8K citations

, , +16

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

Keiko Nakayama, Keiko Nakayama, N. Ishida et al. · Cell · 1996 · 1.6K citations · Full text

, , +17

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

Tullia Lindsten, Andrea J. Ross, Ayala King et al. · Molecular Cell · 2000 · 1.5K citations · Full text

, , +13

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

David W. Threadgill, Andrzej A. Dlugosz, Laura A. Hansen et al. · Science · 1995 · 1.5K citations

, , +13

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

Victor L. J. Tybulewicz, C. Crawford, Peter K. Jackson et al. · Cell · 1991 · 1.3K citations

, , +15

1–5 of 310

Authors

2.1K

  1. RT
    Roderick T. Bronson

    Harvard University, United States

    5 publications · 3.8K citations

    5

    h-index

  2. ST
    Satoru Takahashi

    University of Tsukuba, Japan

    4 publications · 977 citations

    4

    h-index

  3. MY
    Masayuki Yamamoto

    Tohoku University, Japan

    4 publications · 1.1K citations

    4

    h-index

  4. RG
    Robert G. Oshima

    Sanford Burnham Prebys Medical Discovery Institute, United States

    3 publications · 629 citations

    3

    h-index

  5. TL
    Thomas Ludwig

    Heidelberg University, Germany

    3 publications · 1.2K citations

    3

    h-index

1–5 of 2.1K

Institutions

579

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    17 h-index

    48 publications

    18.9K citations

  2. Harvard University

    Cambridge, United States

    13 h-index

    42 publications

    16.6K citations

  3. Baylor College of Medicine

    Houston, United States

    10 h-index

    29 publications

    5.7K citations

  4. National Cancer Institute

    Bethesda, United States

    10 h-index

    23 publications

    11.8K citations

  5. Columbia University

    New York, United States

    9 h-index

    19 publications

    4.8K citations

  6. University of California, San Francisco

    San Francisco, United States

    9 h-index

    23 publications

    4.6K citations

  7. Inserm

    Paris, France

    9 h-index

    44 publications

    8.9K citations

  8. Jackson Laboratory

    Bar Harbor, United States

    8 h-index

    30 publications

    4.9K citations

1–8 of 579

Venues

  1. Molecular and Cellular Biology

    MCB · 24 publications · 3.4K citations

    23

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 3.7K citations

    18

    h-index

  3. PLoS ONE

    14 publications · 628 citations

    13

    h-index

  4. Human Molecular Genetics

    10 publications · 1.2K citations

    10

    h-index

  5. Journal of Biological Chemistry

    JBC · 10 publications · 1.2K citations

    10

    h-index

1–5