Concepedia

Molecular Flexibility Control

Molecular Flexibility Control is a strategic methodology in medicinal chemistry and molecular design that restricts the conformational degrees of freedom of a molecule to stabilize bioactive conformations, thereby enhancing target selectivity, potency, and metabolic stability.

126

Publications

5.8K

Citations

569

Authors

253

Institutions

Publications per year

2017–2026

38

Parents

Publications

126

Acid- and Base-Stable Porous Organic Cages: Shape Persistence and pH Stability via Post-synthetic “Tying” of a Flexible Amine Cage

Ming Liu, Marc A. Little, Kim E. Jelfs et al. · Journal of the American Chemical Society · 2014 · 265 citations

, , +12

The melting points of chain polymers

C. W. Bunn · Journal of Polymer Science · 1955 · 240 citations

, , +17

Achiral molecules in non-centrosymmetric space groups

Elna Pidcock · Chemical Communications · 2005 · 179 citations

, , +16

An Analysis of Porphyrin Molecular FlexibilityUse of Porphyrin Diacids

Beisong Cheng, Orde Q. Munro, Helder M. Marques et al. · Journal of the American Chemical Society · 1997 · 164 citations

, , +16

Relating Molecular Flexibility to Function: A Case Study of Tubulin

Özlem Keskin, Stewart R. Durell, İvet Bahar et al. · Biophysical Journal · 2002 · 162 citations · Full text

, , +14

1–5 of 126

Authors

569

  1. ET
    Elisabetta Teodori

    University of Florence, Italy

    3 publications · 61 citations

    3

    h-index

  2. SS
    Serena Scapecchi

    University of Florence, Italy

    3 publications · 61 citations

    3

    h-index

  3. SD
    Silvia Dei

    University of Florence, Italy

    3 publications · 61 citations

    3

    h-index

  4. MN
    María Novella Romanelli

    University of Florence, Italy

    3 publications · 61 citations

    3

    h-index

  5. CM
    Carl McBride

    Universidad Complutense de Madrid, Spain

    2 publications · 83 citations

    2

    h-index

1–5 of 569

Institutions

253

  1. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    13 publications

    473 citations

  2. Japan Science and Technology Agency

    Tokyo, Japan

    4 h-index

    9 publications

    193 citations

  3. University of Florence

    Florence, Italy

    3 h-index

    9 publications

    145 citations

  4. Northeast Agricultural University

    Harbin, China

    3 h-index

    14 publications

    994 citations

  5. Universität Innsbruck

    Innsbruck, Austria

    3 h-index

    9 publications

    317 citations

  6. University of Cambridge

    Cambridge, United Kingdom

    3 h-index

    3 publications

    259 citations

  7. Florida State University

    Tallahassee, United States

    3 h-index

    6 publications

    328 citations

  8. National Institute of Standards and Technology

    Gaithersburg, United States

    2 h-index

    6 publications

    290 citations

1–8 of 253

Venues

  1. Chemical Communications

    ChemComm · 7 publications · 433 citations

    7

    h-index

  2. CrystEngComm

    6 publications · 247 citations

    6

    h-index

  3. Journal of the American Chemical Society

    JACS · 5 publications · 466 citations

    5

    h-index

  4. Journal of Medicinal Chemistry

    4 publications · 103 citations

    4

    h-index

  5. Chemical Science

    4 publications · 278 citations

    4

    h-index

1–5