Concepedia

Model-based Dose Optimization

Model-Based Dose Optimization is a formal methodology that employs quantitative pharmacometric models to characterize exposure–response relationships and optimally select drug doses by balancing efficacy and safety outcomes within a defined patient population.

93

Publications

3.9K

Citations

479

Authors

225

Institutions

Publications per year

2017–2026

43

Parents

Publications

93

The use and QA of biologically related models for treatment planning: Short report of the TG-166 of the therapy physics committee of the AAPM

X. Allen Li, M. Alber, Joseph O. Deasy et al. · Medical Physics · 2012 · 277 citations

, , +16

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK

Christian Wagner, Ping Zhao, Y. Pan et al. · CPT Pharmacometrics & Systems Pharmacology · 2015 · 268 citations · Full text

, , +13

Model‐Informed Drug Development: Current US Regulatory Practice and Future Considerations

Yaning Wang, Hao Zhu, Rajanikanth Madabushi et al. · Clinical Pharmacology & Therapeutics · 2019 · 209 citations

, , +10

Bayesian decision procedures based on logistic regression models for dose-finding studies

John Whitehead, David P. Williamson · Journal of Biopharmaceutical Statistics · 1998 · 113 citations

, , +17

Assessment of a model based optimization engine for volumetric modulated arc therapy for patients with advanced hepatocellular cancer

Antonella Fogliata, Po‐Ming Wang, Francesca Belosi et al. · Radiation Oncology · 2014 · 111 citations · Full text

, , +17

1–5 of 93

Authors

479

  1. AO
    Andrew Owen

    University of Liverpool, United Kingdom

    4 publications · 125 citations

    4

    h-index

  2. UA
    Usman Arshad

    University of Liverpool, United Kingdom

    3 publications · 88 citations

    3

    h-index

  3. HP
    Henry Pertinez

    University of Liverpool, United Kingdom

    3 publications · 88 citations

    3

    h-index

  4. NJ
    Neill J. Liptrott

    University of Liverpool, United Kingdom

    3 publications · 88 citations

    3

    h-index

  5. GA
    Giancarlo A. Biagini

    Liverpool School of Tropical Medicine, United Kingdom

    3 publications · 88 citations

    3

    h-index

1–5 of 479

Institutions

225

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    5 h-index

    12 publications

    524 citations

  2. Uppsala University

    Uppsala, Sweden

    4 h-index

    9 publications

    127 citations

  3. United States Food and Drug Administration

    Silver Spring, United States

    4 h-index

    19 publications

    3.5K citations

  4. University of Liverpool

    Liverpool, United Kingdom

    4 h-index

    53 publications

    1.6K citations

  5. Bristol-Myers Squibb (United States)

    New York, United States

    3 h-index

    3 publications

    94 citations

  6. Roche (Switzerland)

    Basel, Switzerland

    3 h-index

    5 publications

    260 citations

  7. Centre for Human Drug Research

    Leiden, The Netherlands

    3 h-index

    7 publications

    138 citations

  8. Radboud University Medical Center

    Nijmegen, The Netherlands

    3 h-index

    6 publications

    198 citations

1–8 of 225

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 7 publications · 450 citations

    7

    h-index

  2. British Journal of Clinical Pharmacology

    BJCP · 6 publications · 255 citations

    6

    h-index

  3. CPT Pharmacometrics & Systems Pharmacology

    PSP · 5 publications · 327 citations

    5

    h-index

  4. PLoS ONE

    4 publications · 79 citations

    4

    h-index

  5. Statistics in Medicine

    5 publications · 188 citations

    4

    h-index

1–5