Concepedia

Microtubule Binding Dysfunction

Microtubule Binding Dysfunction is a pathological condition characterized by the impaired ability of tau proteins to properly bind to and stabilize microtubules, resulting in cytoskeletal instability and disrupted intracellular transport in neurons.

8

Publications

1.5K

Citations

52

Authors

27

Institutions

Publications per year

2017–2026

1

Parents

Publications

8

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

Gregory T. Bramblett, Michel Goedert, Ross Jakes et al. · Neuron · 1993 · 898 citations

, , +12

Tau Pathology in Two Dutch Families with Mutations in the Microtubule-Binding Region of Tau

Maria Grazia Spillantini, R. Anthony Crowther, Wouter Kamphorst et al. · American Journal Of Pathology · 1998 · 288 citations

, , +11

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

Teresa Rodríguez-Martín, Amy M. Pooler, Dawn H. W. Lau et al. · Neurobiology of Disease · 2015 · 73 citations · Full text

, , +17

The ΔK280 Mutation in MAP tau Favors Exon 10 Skipping In Vivo

John C. van Swieten, Iraad F. Bronner, Asma Azmani et al. · Journal of Neuropathology & Experimental Neurology · 2007 · 54 citations

, , +17

FTDP-17 Mutations in Tau Alter the Regulation of Microtubule Dynamics

Adria C. LeBoeuf, Sasha F. Levy, Michelle Gaylord et al. · Journal of Biological Chemistry · 2008 · 47 citations · Full text

, , +17

1–5 of 8

Authors

52

  1. JC
    John C. van Swieten

    Erasmus MC, Netherlands

    2 publications · 342 citations

    2

    h-index

  2. PH
    Peter Heutink

    German Center for Neurodegenerative Diseases, Germany

    2 publications · 342 citations

    2

    h-index

  3. WK
    Wouter Kamphorst

    Netherlands Institute for Neuroscience, Netherlands

    2 publications · 342 citations

    2

    h-index

  4. LW
    Leslie Wilson

    University of California, Santa Barbara, United States

    1 publications · 47 citations

    1

    h-index

  5. RW
    Rob Willemsen

    Erasmus University Rotterdam, Netherlands

    1 publications · 54 citations

    1

    h-index

1–5 of 52

Institutions

27

  1. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    2 h-index

    3 publications

    2.1K citations

  2. Medical Research Council

    London, United Kingdom

    2 h-index

    3 publications

    2.1K citations

  3. Erasmus MC

    Rotterdam, The Netherlands

    1 h-index

    5 publications

    270 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    1 h-index

    1 publications

    47 citations

  5. Omuta hospital

    Fukuoka, Japan

    1 h-index

    2 publications

    88 citations

  6. Florida College

    Temple Terrace, United States

    1 h-index

    6 publications

    264 citations

  7. Babraham Institute

    Cambridge, United Kingdom

    1 h-index

    2 publications

    146 citations

  8. Amsterdam UMC Location Vrije Universiteit Amsterdam

    Amsterdam, The Netherlands

    1 h-index

    3 publications

    162 citations

1–8 of 27

Venues

  1. Journal of Biological Chemistry

    JBC · 3 publications · 132 citations

    3

    h-index

  2. Movement Disorders

    1 publications · 44 citations

    1

    h-index

  3. American Journal Of Pathology

    AJP · 1 publications · 288 citations

    1

    h-index

  4. Neurobiology of Disease

    1 publications · 73 citations

    1

    h-index

  5. 1

    h-index

1–5