Concepedia

Microglial Senescence

Microglial Senescence is a biological phenomenon characterized by the irreversible arrest of microglial cell division and the acquisition of a pro-inflammatory, dystrophic phenotype that contributes to neuroimmune dysfunction during aging.

76

Publications

7.5K

Citations

508

Authors

199

Institutions

Publications per year

2017–2026

47

Parents

Publications

76

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

Eugene D. Ponomarev, Tatyana Veremeyko, Natasha S. Barteneva et al. · Nature Medicine · 2010 · 776 citations

, , +14

Dystrophic microglia in the aging human brain

Wolfgang J. Streit, Nicole W. Sammons, Amanda J. Kuhns et al. · Glia · 2003 · 710 citations

, , +17

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration

Christophe Combadière, C. Feumi, William Raoul et al. · Journal of Clinical Investigation · 2007 · 623 citations · Full text

, , +17

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology

Yanling Hu, Gemma Fryatt, Mohammadmersad Ghorbani et al. · Cell Reports · 2021 · 317 citations · Full text

, , +17

Evidence That Aging And Amyloid Promote Microglial Cell Senescence

Barry Flanary, Nicole W. Sammons, Cuong Thach Nguyen et al. · Rejuvenation Research · 2007 · 274 citations

, , +17

1–5 of 76

Authors

508

  1. WJ
    Wolfgang J. Streit

    University of Florida, United States

    8 publications · 1.5K citations

    8

    h-index

  2. BF
    Barry Flanary

    University of Florida, United States

    4 publications · 494 citations

    4

    h-index

  3. TA
    Tim A.O. Muntslag

    University of Southampton, United Kingdom

    2 publications · 338 citations

    2

    h-index

  4. AH
    Adeline H. Machalinski

    University of Oklahoma Health Sciences Center, United States

    2 publications · 79 citations

    2

    h-index

  5. LG
    Li Gan

    Gladstone Institutes, United States

    2 publications · 79 citations

    2

    h-index

1–5 of 508

Institutions

199

  1. University of Florida

    Gainesville, United States

    8 h-index

    18 publications

    4.1K citations

  2. Florida College

    Temple Terrace, United States

    6 h-index

    13 publications

    3.8K citations

  3. Allen Institute for Brain Science

    Seattle, United States

    3 h-index

    7 publications

    868 citations

  4. University of Oklahoma Health Sciences Center

    Oklahoma City, United States

    3 h-index

    24 publications

    1.6K citations

  5. German Center for Neurodegenerative Diseases

    Bonn, Germany

    3 h-index

    12 publications

    1.6K citations

  6. Southampton General Hospital

    Southampton, United Kingdom

    2 h-index

    24 publications

    4.1K citations

  7. Trinity College Dublin

    Dublin, Ireland

    2 h-index

    13 publications

    1.3K citations

  8. Seoul National University

    Seoul, South Korea

    2 h-index

    13 publications

    956 citations

1–8 of 199

Venues

  1. Neurobiology of Aging

    6 publications · 531 citations

    6

    h-index

  2. Journal of Neuroinflammation

    JNI · 5 publications · 403 citations

    5

    h-index

  3. Brain Behavior and Immunity

    3 publications · 250 citations

    3

    h-index

  4. Glia

    3 publications · 898 citations

    3

    h-index

  5. Journal of Clinical Investigation

    JCI · 2 publications · 684 citations

    2

    h-index

1–5