Concepedia

Microglial Lysosomal Dysfunction

Microglial Lysosomal Dysfunction is a pathological condition characterized by impaired lysosomal degradation and clearance functions specifically within microglial cells, leading to aberrant neuroinflammatory responses and accumulation of toxic substrates in the central nervous system.

54

Publications

4.8K

Citations

563

Authors

207

Institutions

Publications per year

2017–2026

43

Parents

Publications

54

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

Fiona Pickford, Eliezer Masliah, Markus Britschgi et al. · Journal of Clinical Investigation · 2008 · 1.1K citations

, , +17

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease

Souvarish Sarkar, Emir Malovic, Dilshan S. Harishchandra et al. · npj Parkinson s Disease · 2017 · 283 citations · Full text

, , +17

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Jian Jing Siew, Huimei Chen, Huan‐Yuan Chen et al. · Nature Communications · 2019 · 235 citations · Full text

, , +17

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

Sahabuddin Ahmed, Mohit Kwatra, Samir Ranjan Panda et al. · Brain Behavior and Immunity · 2020 · 217 citations

, , +17

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice

Yoshinori Tanaka, Takashi Matsuwaki, Keitaro Yamanouchi et al. · Neuroscience · 2013 · 157 citations

, , +17

1–5 of 54

Authors

563

  1. KO
    Kazuhiro Ohmi

    University of California, Los Angeles, United States

    2 publications · 279 citations

    2

    h-index

  2. SA
    Susanne A. Schneider

    University College London, United Kingdom

    2 publications · 119 citations

    2

    h-index

  3. AC
    Alessio Colombo

    German Center for Neurodegenerative Diseases, Germany

    2 publications · 119 citations

    2

    h-index

  4. AK
    Arthi Kanthasamy

    Iowa State University, United States

    2 publications · 355 citations

    2

    h-index

  5. ST
    Sabina Tahirović

    German Center for Neurodegenerative Diseases, Germany

    2 publications · 119 citations

    2

    h-index

1–5 of 563

Institutions

207

  1. Cornell University

    Ithaca, United States

    4 h-index

    18 publications

    1.2K citations

  2. German Center for Neurodegenerative Diseases

    Bonn, Germany

    3 h-index

    19 publications

    1.1K citations

  3. University of California, San Francisco

    San Francisco, United States

    3 h-index

    7 publications

    167 citations

  4. University of Washington

    Seattle, United States

    3 h-index

    4 publications

    245 citations

  5. Stanford University

    Stanford, United States

    3 h-index

    22 publications

    6.9K citations

  6. Inserm

    Paris, France

    3 h-index

    4 publications

    362 citations

  7. Sun Yat-sen University

    Guangzhou, China

    2 h-index

    16 publications

    508 citations

  8. Munich Cluster for Systems Neurology

    Munich, Germany

    2 h-index

    6 publications

    357 citations

1–8 of 207

Venues

  1. Journal of Neuroinflammation

    JNI · 5 publications · 263 citations

    5

    h-index

  2. Nature Communications

    3 publications · 407 citations

    3

    h-index

  3. Journal of Neuroscience

    2 publications · 281 citations

    2

    h-index

  4. Science Advances

    2 publications · 119 citations

    2

    h-index

  5. Science Translational Medicine

    STM · 2 publications · 156 citations

    2

    h-index

1–5