Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

Fenghua Hu, Thihan Padukkavidana, Christian Bjerggaard Vægter, +5

Neuron

Alzheimer's DiseaseFrontotemporal Dementia ProteinDementiaAutophagyEndocytic Pathway +8

Control of the DNA Damage Checkpoint by Chk1 and Rad53 Protein Kinases Through Distinct Mechanisms

Yolanda Sánchez, Jeff Bachant, Hong Wang, +4

Science

ChromatinGenome InstabilityDna DamageCell RegulationCell Division +13

Mrc1 transduces signals of DNA replication stress to activate Rad53

Annette A. Alcasabas, Alexander J. Osborn, Jeff Bachant, +7

Nature Cell Biology

ChromatinGenome InstabilityChromatin RemodelingNatural SciencesDna Replication +4

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

Peter M. Sullivan, Xiaolai Zhou, Adam M. Robins, +4

Acta Neuropathologica Communications

MitophagyGeneticsCell DeathAutophagy InitiationCell Autophagy +15

Regulation of the Bub2/Bfa1 GAP Complex by Cdc5 and Cell Cycle Checkpoints

Fenghua Hu, Yanchang Wang, Dou Liu, +3

Cell

Cell Cycle CheckpointsSignaling PathwayCell RegulationCell DivisionMedicine +6

The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function

Owen A. Brady, Yanqiu Zheng, Kira A. Murphy, +2

Human Molecular Genetics

Lysosomal MorphologyNeurodegenerative DiseasesAmyotrophic Lateral SclerosisDevelopmental BiologyGenetics +12

Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1

Owen A. Brady, Peter S. Meng, Yanqiu Zheng, +2

Journal of Neurochemistry

Molecular RegulationMolecular BiologyCellular PhysiologySignaling PathwayAutophagy +16

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

Xiaolai Zhou, Lirong Sun, Francisco Meirelles Bastos de Oliveira, +5

The Journal of Cell Biology

ProteasomeMolecular BiologyCytoskeletonLow DensityAutophagy +14

Asf1 links Rad53 to control of chromatin assembly

Fenghua Hu, Annette A. Alcasabas, Stephen J. Elledge

Genes & Development

ChromatinGenome InstabilityTranscriptional RegulationChromatin StructureChromatin Remodeling +12

Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells

Qing Miao, Yuan Gao, Kenneth Harrison, +6

Proceedings of the National Academy of Sciences

Endothelial CellsImmunologyNogo-b ReceptorCellular PhysiologyInflammation +15